胶原蛋白酸性溶液 I-PC、I-AC Atelocollagen/Native Collagen Acidic Solutions

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  • 参考文献

胶原蛋白酸性溶液 I-PC、I-AC胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

Atelocollagen/Native Collagen Acidic Solutions

胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions



◆概要


本产品为牛皮来源的高纯度胶原蛋白酸性溶液,适用于制备 3D 培养和共培养用支架(支架材料)的胶原蛋白凝胶,以及包被培养皿或培养板等器材。有 I-PC(去端肽胶原蛋白)与 I-AC(天然胶原蛋白)两种类型,去端肽胶原蛋白通过蛋白酶切断天然胶原蛋白分子两端存在的肽。

胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

◆应用


胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

包被胶原蛋白


胶原蛋白凝胶中的 3D 培养


在胶原蛋白凝胶上方培养


胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

胶原蛋白凝胶共培养

◆特点


● I-PC(去端肽胶原蛋白)和 I-AC(天然胶原蛋白)中和时,在生理条件下会凝胶化(纤维化)。

● 可选择3mg/mL 与5mg/mL 两种浓度,分别适用于制备包被、3D 培养和共培养用支架(支架材料)的胶原蛋白凝胶。

● 区别于可溶性底物膜制备品,不含细胞来源的生理活性物质、核酸和 MMP 等,可准确评估实验结果。



◆胶原蛋白种类

胶原蛋白酸性溶液 I-PC:牛皮来源去端肽胶原蛋白

胶原蛋白酸性溶液 I-AC:牛皮来源天然胶原蛋白



35 mm 胶原海绵培养皿

◆原理

胶原海绵细胞培养是以胶原蛋白为基础新开发出来的,可用于细胞 3D 培养。多孔胶原海绵是由牛跟腱提取的不溶性I型胶原蛋白制备而成。细胞可渗透入海绵,朝不同方向增殖。

◆优点特色

       所有产品均已灭菌 

◆案例应用

细胞在海绵上培养


产品编号

品名

包装

储存

KOU-CS-35

Collagen sponge for35mm culture dish Bovine tendon   Sterile

5pcs/box

RT

 


Atelocollagen, Permeable membrane for50mmculture dish

◆原理

从牛跟腱中提取的Ⅰ型胶原蛋白制备的可渗透性胶原蛋白膜可用于单层或双层细胞培养。此胶原蛋白膜特别适用于研究在膜两侧培养的不同细胞间的分子相互作用,相互关系。膜的可渗透性允许氨基酸,蛋白质等小分子自由通过胶原蛋白膜,这对于细胞间的营养吸收,物质交换有重要作用。

◆优点特色


 两种不同细胞可在膜两侧生长,因此特别适合研究细胞或小分子相互间的作用。

 可渗透性膜非常适合细胞培养,也适合人工皮肤,人工胰腺等其它人工器官的培养。

产品编号

品名

规格

储存

KOU-MEN-01

Atelocollagen, Permeable membrane for50mmculture   dish

(33mm)Bovine   dermis   Sterile

5pcs/box

-20℃

 


 

Atelocollagen, Honeycomb sponge

◆原理

“蜂窝状”海绵的结构比较特殊,它的孔径大约 200-400μm,密集地向一个方向排列,因此细胞可以顺着小孔渗透增殖。这样的结构,有利于海绵内部的细胞吸收营养物质,排出生物代谢物质。细胞在空腔内增殖,并形成统一的细胞团。

优势:从牛跟腱中提取胶原蛋白制备“蜂窝状”海绵,可以用胶原酶降解此海绵。


 

胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

Honeycomb sponge 的电镜图

 

产品编号

品名

规格

储存

KOU-CSH-10

Atelocollagen Honeycomb sponge Bovine dermis

Size: about 3X3X2 mm/sponge   total surface area:2000cm2/g  weight per volume:   12-13mg/ml sterile

100mg/btl

室温

胶原蛋白酸性溶液 I-PC、I-AC                              Atelocollagen/Native Collagen Acidic Solutions

AteloCell 细胞培养胶原.pdf

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10.

Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway.Maruyama K, Sakisaka Y, Suto M, Tada H, Nakamura T, Yamada S, Nemoto E.Front Physiol. 2018 Jun 28;9:802. PMID: 30002631


11.

"All-in-one" in vitro selection of collagen-binding vascular endothelial growth factor.Park SH, Uzawa T, Hattori F, Ogino S, Morimoto N, Tsuneda S, Ito Y.Biomaterials. 2018 Apr;161:270-278. PMID: 29425847


12.

Alkyne-Functionalized Cationic Polysiloxane Polymers Conjugated with Targeting Molecules by Click Reactions for DNA Delivery.Kihara, Yoshihiko; Maeda, Riho; Imaizumi, Azusa; Ichikawa, Tsukasa; Nemoto, Nobukatsu; Ishihara, Tsutomu; Hirano, Nobutaka; Haruki, Mitsuru.Journal of Nanoscience and Nanotechnology, Volume 17, Number 7, July 2017, pp. 5081-5089(9).


13.

Identification of laminin α5 short arm peptides active for endothelial cell attachment and tube formation.Kikkawa Y, Sugawara Y, Harashima N, Fujii S, Ikari K, Kumai J, Katagiri F, Hozumi K, Nomizu M.J Pept Sci. 2017 Jul;23(7-8):666-673. PMID: 28220599


14.

Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C.Hanaki T, Horikoshi Y, Nakaso K, Nakasone M, Kitagawa Y, Amisaki M, Arai Y, Tokuyasu N, Sakamoto T, Honjo S, Saito H, Ikeguchi M, Yamashita K, Ohno S, Matsura T.BiochimBiophys Acta. 2016 Nov;1860(11 Pt A):2404-15. PMID: 27424921


15.

Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.Kitakaze K, Mizutani Y, Sugiyama E, Tasaki C, Tsuji D, Maita N, Hirokawa T, Asanuma D, Kamiya M, Sato K, Setou M, Urano Y, Togawa T, Otaka A, Sakuraba H, Itoh K.J Clin Invest. 2016 May 2;126(5):1691-703. PMID: 27018595


16.

Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts.Keisuke Kitakaze, Chikako Tasaki, Youichi Tajima, Takatsugu Hirokawa, Daisuke Tsuji, Hitoshi Sakuraba, Kohji Itoh.Biochemistry and Biophysics Reports, Volume 7, September 2016, Pages 157-163.


17.

Engineered bone marrow-derived cell sheets restore structure and function of radiation-injured rat urinary bladders.Imamura T, Ogawa T, Minagawa T, Yokoyama H, Nakazawa M, Nishizawa O, Ishizuka O.Tissue Eng Part A. 2015 May;21(9-10):1600-10. PMID: 25669695


18.

Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.Kobayashi S, Nakamura TY, Wakabayashi S.J Mol Cell Cardiol. 2015 Jul;84:133-42. PMID: 25935310


19.

Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase.Donai K, Kiyono T, Eitsuka T, Guo Y, Kuroda K, Sone H, Isogai E, Fukuda T.J Biotechnol. 2014 Apr 20;176:50-7. PMID: 24589663


20.

Analysis of beat fluctuations and oxygen consumption in cardiomyocytes by scanning electrochemical microscopy.Hirano Y, Kodama M, Shibuya M, Maki Y, Komatsu Y.Anal Biochem. 2014 Feb 15;447:39-42. PMID: 24252541


21.

Establishment of cell lines derived from the genus Macaca through controlled expression of cell cycle regulators.Kuroda K, Kiyono T, Eitsuka T, Isogai H, Takahashi K, Donai K, Isogai E, Fukuda T.J Cell Biochem. 2015 Feb;116(2):205-11. PMID: 25187009


22.

Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.Suzuki R, Nemoto E, Shimauchi H.Exp Cell Res. 2014 Apr 15;323(1):232-41. PMID: 24561081


23.

Probing the microenvironmental conditions for induction of superficial zone protein expression.Mhanna R, Oztürk E, Schlink P, Zenobi-Wong M.Osteoarthritis Cartilage. 2013 Dec;21(12):1924-32 PMID: 23978656


24.

Induction of albumin expression in HepG2 cells using immobilized simplified recombinant fibronectin protein.Nishida Y, Taniguchi A.In Vitro Cell Dev Biol Anim. 2013 Jun;49(6):400-7. ID: 23649815.


25.

Survival of primary human hepatocytes and death of induced pluripotent stem cells in media lacking glucose and arginine.Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.PLoS One. 2013 Aug 14;8(8):e71897. PMID: 23967260


26.

The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation.Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F, Takahashi S.Mol Cell Biol. 2013 May;33(10):1991-2003. PMID: 23478262


27.

NIH3T3 cells overexpressing CD98 heavy chain resist early G1 arrest and apoptosis induced by serum starvation.Hara K, Ueda S, Ohno Y, Tanaka T, Yagi H, Okazaki S, Kawahara R, Masayuki T, Enomoto T, Hashimoto Y, Masuko K, Masuko T.Cancer Sci. 2012 Aug;103(8):1460-6. PMID:22497681


28.

N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model.Ishii-Osai Y, Yamashita T, Tamura Y, Sato N, Ito A, Honda H, Wakamatsu K, Ito S, Nakayama E, Okura M, Jimbow K.J Dermatol Sci. 2012 Jul;67(1):51-60. PMID:22622238


29.

Activation of macrophage-stimulating protein by human airway trypsin-like protease.Orikawa H, Kawaguchi M, Baba T, Yorita K, Sakoda S, Kataoka H.FEBS Lett. 2012 Feb 3;586(3):217-21. PMID:22245154


30.

Effects of Hypoxia-Inducible Factor-1α Chemical Stabilizer, CoCl(2) and Hypoxia on Gene Expression of CYP3As in Human Fetal Liver Cells.Suzuki E, Matsunaga T, Aonuma A, Sasaki T, Nagata K, Ohmori S.Drug MetabPharmacokinet. 2012;27(4):398-404. PMID: 22277676


31.

Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR overexpressed in human fetal liver cells.Takezawa T, Matsunaga T, Aikawa K, Nakamura K, Ohmori S.Drug MetabPharmacokinet. 2012;27(4):430-8. PMID:22333269


32.

Cyclic stretch induces upregulation of endothelin-1 with keratinocytes in vitro: possible role in mechanical stress-induced hyperpigmentation.Kurita M, Okazaki M, Fujino T, Takushima A, Harii K.BiochemBiophys Res Commun. 2011 May 27;409(1):103-7. PMID: 21557930


33.

The TRPV4 channel is a novel regulator of intracellular Ca2+ in human esophageal epithelial cells.Ueda T, Shikano M, Kamiya T, Joh T, Ugawa S.Am J PhysiolGastrointest Liver Physiol. 2011 Jul;301(1):G138-47. PMID:21493730


34.

Expansion and characterization of adipose tissue-derived stromal cells cultured with low serum medium.Hattori H, Nogami Y, Tanaka T, Amano Y, Fukuda K, Kishimoto S, Kanatani Y, Nakamura S, Takase B, Ishihara M.J Biomed Mater Res B Appl Biomater. 2008 Oct;87(1):229-36. PMID: 18496860


35.

Nuclear deformation and expression change of cartilaginous genes during in vitro expansion of chondrocytes.Hoshiba T, Yamada T, Lu H, Kawazoe N, Tateishi T, Chen G.BiochemBiophys Res Commun. 2008 Oct 3;374(4):688-92. PMID: 18675249


36.

Visible light regulates neurite outgrowth of nerve cells.Higuchi A, Watanabe T, Noguchi Y, Chang Y, Chen WY, Matsuoka Y.Cytotechnology. 2007 Jul;54(3):181-8. PMID: 18832797


37.

Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T, Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K.Am J Physiol Renal Physiol. 2007 Oct;293(4):F1363-72. PMID: 17699553


38.

Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone.Makino H, Miyamoto Y, Sawai K, Mori K, Mukoyama M, Nakao K, Yoshimasa Y, Suga S.Diabetes. 2006 Oct;55(10):2747-56. PMID: 17003339


39.

Regulation of neurite outgrowth by intermittent irradiation of visible light.Higuchi A, Watanabe T, Matsubara Y, Matsuoka Y, Hayashi S.J Phys Chem B. 2005 Jun 2;109(21):11033-6. PMID: 16852344


40.

Platelet-rich plasma provides nucleus for mineralization in cultures of partially differentiated periodontal ligament cells.Kawase T, Okuda K, Saito Y, Amizuka N, Suzuki H, Yoshie H.In Vitro Cell Dev Biol Anim. 2005 May-Jun;41(5-6):171-6. PMID: 16153151


41.

Visible light is able to regulate neurite outgrowth.Higuchi A, Kitamura H, Shishimine K, Konishi S, Yoon BO, Hara M.J Biomater Sci Polym Ed. 2003;14(12):1377-88. PMID: 14870941


42.

A simple electroporation method for the introduction of plasmids into cells cultured on coverslips for histochemical examination.TAKATA Kuniaki ; TAKAHASHI Yukiko ; MATSUZAKI Toshiyuki ; TAJIKA Yuki ; SUZUKI Takeshi ; AOKI Takeo ; HAGIWARA Haruo.Act Histochem Cytochem,2003; 36 (4):317-23.


43.

Synergistic effect of BMP-2 and ascorbate on the phenotypic expression of osteoblastic MC3T3-E1 cells.Torii Y, Hitomi K, Tsukagoshi N.Mol Cell Biochem. 1996 Dec 6;165(1):25-9. PMID: 8974078

I-PC支架制备/包被

1.

Effect of Cyclic Stretch on Tissue Maturation in Myoblast-Laden Hydrogel Fibers.Bansai S, Morikura T, Onoe H, Miyata S.Micromachines (Basel). 2019 Jun 15;10(6). pii: E399. PMID: 31208059


2.

Bone Marrow Cells Inhibit BMP-2-Induced Osteoblast Activity in the Marrow Environment.Nguyen HT, Ono M, Oida Y, Hara ES, Komori T, Akiyama K, Nguyen HTT, Aung KT, Pham HT, Tosa I, Takarada T, Matsuo K, Mizoguchi T, Oohashi T, Kuboki T.J Bone Miner Res. 2019 Feb;34(2):327-332. PMID: 30352125


3.

Establishment of perpendicular protrusion of type I collagen on TiO2 nanotube surface as a priming site of peri-implant connective fibers.Nojiri T, Chen CY, Kim DM, Da Silva J, Lee C, Maeno M, McClelland AA, Tse B, Ishikawa-Nagai S, Hatakeyama W, Kondo H, Nagai M.J Nanobiotechnology. 2019 Mar 1;17(1):34. PMID: 30823919


4.

Microdimpled surface atelocollagen maintains primary human hepatocytes in culture and may promote their functionality compared with collagen coat culture.Sato T, Semura K, Fujimoto I.Int J Mol Med. 2019 Sep;44(3):960-972. PMID: 31257473


5.

Three-dimensional bone formation including vascular networks derived from dental pulp stem cells in vitro.Watanabe M, Ohyama A, Ishikawa H, Tanaka A.Hum Cell. 2019 Apr;32(2):114-124. PMID: 30523537


6.

Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells.Koh I, Furusawa K, Haga H.Sci Rep. 2018 Sep 17;8(1):13901. PMID: 30224813


7.

Effects of Three-Dimensional Culture of Mouse Calvaria-Derived Osteoblastic Cells in a Collagen Gel with a Multichannel Structure on the Morphogenesis Behaviors of Engineered Bone TissuesSaki Yahata, Kazuya Furusawa, Kei Nagao, Masahiro Nakajima, and Toshio Fukuda.ACS Biomater. Sci. Eng., 2017, 3 (12), pp 3414–3424.


8.

Bone and Gingival Connective Tissue Responses towards Nanosecond-Pulsed Laser-Treated Titanium ImplantsYugo Fukayo, Tsuyoshi Amemiya, KazutoshiNakaoka, Masayoshi Mizutani, Jun Komotori, Yoshiki Hamada, Tohru HayakawaJournal of Hard Tissue Biology Vol. 25 (2016) No. 2 p. 181-194.


9.

Systemically replicated organic and inorganic bony microenvironment for new bone formation generated by a 3D printing technology. Wan-Gun La, Jinah Jang, Byoung Soo Kim, Min Suk Lee, Dong-Woo Cho and Hee Seok YangRSC Adv., 2016,6, 11546-11553


10.

Application of Multichannel Collagen Gels in Construction of Epithelial Lumen-like Engineered Tissues.Furusawa K, Mizutani T, Machino H, Yahata S, Fukui A, Sasaki N.ACS Biomater. Sci. Eng., 2015, 1 (7), pp 539–548.


11.

Expansion of mouse hematopoietic progenitor cells in three-dimensional cocultures on frozen-thawed stromal cell layers formed within porous scaffolds.Miyoshi H, Morita M, Ohshima N, Sato C.Exp Hematol. 2015 Feb;43(2):115-24. PMID: 25461256


12.

Tissue Response of Surface-Modified Three-Dimensional Titanium Fiber Structure.Amemiya T, Fukayo Y, Nakaoka K, Hamada Y.J Hard Tissue Biol. 23(2), 137-148, 2014-04


13.

The use of gene activated matrix to mediate effective SMAD2 gene silencing against hypertrophic scar.Yin L, Zhao X, Ji S, He C, Wang G, Tang C, Gu S, Yin C.Biomaterials. 2014 Mar;35(8):2488-98. PMID: 24388384


14.

Multiscale analysis of changes in an anisotropic collagen gel structure by culturing osteoblasts.Hanazaki Y, Masumoto J, Sato S, Furusawa K, Fukui A, Sasaki N.ACS Appl Mater Interfaces. 2013 Jul 10;5(13):5937-46. PMID: 23806015


15.

Three-dimensional culture of mouse bone marrow cells on stroma formed within a porous scaffold: influence of scaffold shape and cryopreservation of the stromal layer on expansion of haematopoietic progenitor cells.Miyoshi H, Ohshima N, Sato C.J Tissue Eng Regen Med. 2013 Jan;7(1):32-8. PMID: 22081538


16.

Cartilage tissue engineering with controllable shape using a poly(lactic-co-glycolic acid)/collagen hybrid scaffold.Wenda Dai, Zhenjun Yao, Jian Dong, Naoki Kawazoe, Chi Zhang, Guoping Chen. J BioactCompat Poly. May 2013 vol. 28 no. 3 247-257.


17.

Studies on the formation mechanism and the structure of the anisotropic collagen gel prepared by dialysis-induced anisotropic gelation.Furusawa K, Sato S, Masumoto J, Hanazaki Y, Maki Y, Dobashi T, Yamamoto T, Fukui A, Sasaki N.Biomacromolecules. 2012 Jan 9;13(1):29-39. PMID: 22107030


18.

Development of biodegradable scaffolds based on magnetically guided assembly of magnetic sugar particles.Hu C, Uchida T, Tercero C, Ikeda S, Ooe K, Fukuda T, Arai F, Negoro M, Kwon G.J Biotechnol. 2012 May 31;159(1-2):90-8. PMID:22361001


19.

Application of collagen hydrogel/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs.Kosen Y, Miyaji H, Kato A, Sugaya T, Kawanami M.J Periodontal Res. 2012 Oct;47(5):626-34. PMID:22443229


20.

Spatial immobilization of bone morphogenetic protein-4 in a collagen-PLGA hybrid scaffold for enhanced osteoinductivity.Lu H, Kawazoe N, Kitajima T, Myoken Y, Tomita M, Umezawa A, Chen G, Ito Y.Biomaterials. 2012 Sep;33(26):6140-6. PMID:22698726


21.

Micropatterned angiogenesis induced by poly(d,l-lactic-co-glycolic acid) mesh-structured scaffolds.Hwan H Oh, Hongxu Lu, Naoki Kawazoe, Guoping Chen. J BioactCompat Pol. March 2012 vol. 27 no. 2 97-106.


22.

Three-dimensional culture of mouse bone marrow cells within a porous polymer scaffold: effects of oxygen concentration and stromal layer on expansion of haematopoietic progenitor cells.Miyoshi H, Murao M, Ohshima N, Tun T.J Tissue Eng Regen Med. 2011 Feb;5(2):112-8. PMID:20653040


23.

Ectopic Bone Induction by BMP-loaded Collagen Scaffold and Bone Marrow Stromal Cell Sheet.Kana INOUE, Hirofumi MIYAJI, Tsutomu SUGAYA and Masamitsu KAWANAMI. J Oral Tissue Eng. Vol. 8 (2010) , No. 1 pp.19-29.


24.

A cell leakproof PLGA-collagen hybrid scaffold for cartilage tissue engineering.Kawazoe N, Inoue C, Tateishi T, Chen G.Biotechnol Prog. 2010 May-Jun;26(3):819-26. PMID: 20039440


25.

Efficacy of Tooth Extraction Wound Protection Made of Atelocollagen Sponge (TRE-641): A Pilot Study in DogsMakoto Hirota), Nobuyuki Mizuki), Shinjiro Aoki), Susumu Omura), Kei Watanuki), Tomomichi Ozawa), Toshinori Iwai), Yoshiro Matsui) and Iwai Tohnai. Journal of Hard Tissue Biology Vol. 18 (2009) , No. 2 pp.89-94.


26.

Three-dimensional Cultures of Rat Pancreatic RIN-5F Cells in Porous PLGA-collagen Hybrid Scaffolds.Naoki Kawazoe, Xiaoting Lin, Tetsuya Tateishi, and Guoping Chen.J BioactCompat Pol. January 2009 24: 25-42.


27.

Stimulating effects of fibroblast growth factors on hepatic function of fetal liver cells synergistically with oncostatin M in three-dimensional culture.Minagawa K, Koyama T, Miyoshi H.J BiosciBioeng. 2009 Mar;107(3):307-11. PMID: 19269598


28.

Recombinant human bone morphogenetic protein-2/atelocollagen composite as a new material for ossicular reconstruction.Takeuchi A, Tsujigiwa H, Murakami J, Kawasaki A, Takeda Y, Fukushima K, Rodriguez AP, Nagatsuka H, Yamada M, Nishizaki K.J Biomed Mater Res A. 2009 Apr;89(1):36-45. PMID: 18404714


29.

Multiwalled carbon nanotube coating on titanium.Terada M, Abe S, Akasaka T, Uo M, Kitagawa Y, Watari F.Biomed Mater Eng. 2009;19(1):45-52. PMID: 19458445


30.

Development of biodegradable scaffolds based on patient-specific arterial configuration.Uchida T, Ikeda S, Oura H, Tada M, Nakano T, Fukuda T, Matsuda T, Negoro M, Arai F.J Biotechnol. 2008 Jan 20;133(2):213-8. PMID: 17868940


31.

Evaluation of diaphragmatic hernia repair using PLGA mesh-collagen sponge hybrid scaffold: an experimental study in a rat model.Urita Y, Komuro H, Chen G, Shinya M, Saihara R, Kaneko M.Pediatr Surg Int. 2008 Sep;24(9):1041-5. PMID: 18668247


32.

Establishment of Nanofiber Preparation Technique by Electrospinning.Y Yamashita, F Ko, H Miyake, A HigashiyamaSen'IGakkaishi. 2008 Vol. 64 No. 1 P 24-28.


33.

In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding.Yokota T, Ichikawa H, Matsumiya G, Kuratani T, Sakaguchi T, Iwai S, Shirakawa Y, Torikai K, Saito A, Uchimura E, Kawaguchi N, Matsuura N, Sawa Y.J Thorac Cardiovasc Surg. 2008 Oct;136(4):900-7. PMID: 18954628


34.

Effects of oncostatin M on secretion of vascular endothelial growth factor and reconstruction of liver-like structure by fetal liver cells in monolayer and three-dimensional cultures.Ehashi T, Koyama T, Ookawa K, Ohshima N, Miyoshi H.Biomed Mater Res A. 2007 Jul;82(1):73-9. PMID: 17269136


35.

Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds.Hirata I, Nomura Y, Ito M, Shimazu A, Okazaki M.J Artif Organs. 2007;10(4):212-7. PMID: 18071850


36.

Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils.Kato K, Sato H, Iwata H.Bioconjug Chem. 2007 Nov-Dec;18(6):2137-43. PMID: 17894450


37.

Osteochondral tissue engineering using a PLGA–collagen hybrid mesh.Guoping Chen, Junzo Tanaka, Tetsuya Tateishi.Materials Science and Engineering: C, Volume 26, Issue 1, January 2006, Pages 124-129.


38.

Polymer Scaffolds for Tissue Engineering.G. P. Chen, M. Tanaka, T. Tateishi.Advances in Science and Technology, Vol. 49, pp. 136-141, Oct. 2006.


39.

Preparation of a biphasic scaffold for osteochondral tissue engineering.Guoping Chen, Takashi Sato, Junzo Tanaka, Tetsuya Tateishi.Materials Science and Engineering: C, Volume 26, Issue 1, January 2006, Pages 118-123.


40.

Three-dimensional culture of porcine fetal liver cells for a bioartificial liver.Ehashi T, Ohshima N, Miyoshi H.J Biomed Mater Res A. 2006 Apr;77(1):90-6. PMID: 16355413


41.

Osteoblast Behavior at the Surface of CO3Ap-Collagen Sponges.M. Okazaki, Y. Tieliewuhan, I. Hirata.Key Engineering Materials, Vols. 309-311, pp. 989-992, May. 2006.


42.

Albumin and urea production by hepatocytes cultured on polyurethane foaming membranes coated with extracellular matrix.Akon Higuchi, Masuhiro Satoh, Kenichi Kobayashi, Chong Su Cho, Toshihiro Akaike, Tae Moon Tak, Satsuki Egashira, Yuki Matsuoka, Shizue Hayashi Natori.Journal of Membrane Science, Volume 280, Issues 1–2, 1 September 2006, Pages 983-989.


43.

Detailed consideration of physicochemical properties of CO3apatites as biomaterials in relation to carbonate content using ICP, X-ray diffraction, FT-IR, SEM, and HR-TEM.Yokota R, Hayashi H, Hirata I, Miake Y, Yanagisawa T, Okazaki M.Dent Mater J. 2006 Sep;25(3):597-603. PMID: 17076333


44.

Culturing of skin fibroblasts in a thin PLGA-collagen hybrid mesh.Chen G, Sato T, Ohgushi H, Ushida T, Tateishi T, Tanaka J.Biomaterials. 2005 May;26(15):2559-66. PMID: 15585258


45.

Albumin and urea production by hepatocytes cultured on extracellular matrix proteins-conjugated poly(vinyl alcohol) membranes.Higuchi A, Kurihara M, Kobayashi K, Cho CS, Akaike T, Hara M.J Biomater Sci Polym Ed. 2005;16(7):847-60. PMID: 16128292


46.

Temperature-dependent cell detachment on Pluronic gels.Higuchi A, Yamamoto T, Sugiyama K, Hayashi S, Tak TM, Nakagawa T.Biomacromolecules. 2005 Mar-Apr;6(2):691-6. PMID: 15762631


47.

SEM observation of collagen fibrils secreted from the body surface of osteoblasts on a CO3apatite-collagen sponge.Hirata I, Nomura Y, Tabata H, Miake Y, Yanagisawa T, Okazaki M.Dent Mater J. 2005 Sep;24(3):460-4. PMID: 16279740


48.

Effects of biomaterials on cell adhesion of human periodontal ligament fibroblasts and fibronectin adsorption.Y. Iwamatsu-Kobayashi, D. Nishihara, M. Hirata, K. Kindaichi, M. Komatsu.International Congress Series, Volume 1284, September 2005, Pages 334-335.


49.

Cell adhesion of bone marrow cells, chondrocytes, ligament cells and synovial cells on a PLGA–collagen hybrid mesh.Guoping Chen, Dechang Liu, Norio Maruyama, Hajime Ohgushi, Junzo Tanaka, Tetsuya Tateishi.Materials Science and Engineering: C. Volume 24, Issues 6–8, 1 December 2004, Pages 867–873.


50.

Application of PLGA-collagen hybrid mesh for three-dimensional culture of canine anterior cruciate ligament cells.Guoping Chen, Takashi Sato, MasatakaSakane, Hajime Ohgushi, Takashi Ushida, Junzo Tanaka, Tetsuya Tateishi.Materials Science and Engineering: C. Volume 24, Issues 6–8, 1 December 2004, Pages 861–866.


51.

Regeneration of cartilage tissue by combination of canine chondrocyte and a hybrid mesh scaffold.Guoping Chen, Takashi Sato, Takashi Ushida, Rei Hirochika, NaoyukiOchiai, Tetsuya Tateishi.Materials Science and Engineering: C. Volume 24, Issue 3, 1 April 2004, Pages 373–378.


52.

Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography.Itoh M, Shimazu A, Hirata I, Yoshida Y, Shintani H, Okazaki M.Biomaterials. 2004 Jun;25(13):2577-83. PMID: 14751743


53.

Osteoblast proliferation behavior and bone formation on and in CO3apatite-collagen sponges with a porous hydroxyapatite frame.Tieliewuhan Y, Hirata I, Sasaki A, Minagi H, Okazaki M.Dent Mater J. 2004 Sep;23(3):258-64. PMID: 15510851


54.

Custom-shaping system for bone regeneration by seeding marrow stromal cells onto a web-like biodegradable hybrid sheet.Tsuchiya K, Mori T, Chen G, Ushida T, Tateishi T, Matsuno T, Sakamoto M, Umezawa A.Cell Tissue Res. 2004 May;316(2):141-53. PMID: 14999559


55.

Bone augmentation using rhGDF-5-collagen composite.Kuniyasu H, Hirose Y, Ochi M, Yajima A, Sakaguchi K, Murata M, Pohl J.Clin Oral Implants Res. 2003 Aug;14(4):490-9. PMID: 12869012

I-PC凝胶上方培养、其他

1.

In Vitro and In Vivo Comparison of Different Types of Rabbit Mesenchymal Stem Cells for Cartilage Repair.Khalilifar MA, BaghabanEslaminejad MR, Ghasemzadeh M, Hosseini S, Baharvand H.Cell J. 2019 Jul;21(2):150-160. PMID: 30825288

.

2.

Temperature dependence of synchronized beating of cultured neonatal rat heart-cell networks with increasing age measured by multi-electrode arrays.Uchida T, Kitora R, Gohara K (2018). Trends Med 18, Volume 18(4): 1-10.


3.

Spontaneous acquisition of infinite proliferative capacity by a rabbit corneal endothelial cell line with maintenance of phenotypic and physiological characteristics.Kageyama T, Hayashi R, Hara S, Yoshikawa K, Ishikawa Y, Yamato M, Nishida K.J Tissue Eng Regen Med. 2017 Apr;11(4):1057-1064. PMID: 25758102


4.

Electrochemical Sensing of Casein Based on the Interaction between Its Phosphate Groups and a Ruthenium(III) Complex.Inaba I1, Kuramitz H, Sugawara K.Anal Sci. 2016;32(8):853-9. PMID: 27506711


5.

Biochemical Mechanism of Titanium Fixation into Living Bone: Acid Soluble Phosphoproteins in Bone Binds with Titanium and Induced Endochondral Ossification in vivo.Yoshinori KUBOKI, Kimitoshi YAGAMI, Michiko TERADA-NAKAISHI, Toshitake FURUSAWA, Yasuko NAKAOKI, Masaaki KURASAKI.J. Oral Tissue Engin. 2017;15(2):109-118.


6.

Time of flight-secondary ion mass spectrometry analysis of protein adsorption on a polyvinylidene difluoride surface modified by ion irradiation.Okuji S, Kitazawa H, Takeda Y.Colloids Surf B Biointerfaces. 2016 Dec 1;148:249-254. PMID: 27616065


7.

Surface Modification of PMMA to Improve Adhesion to Corneal Substitutes in a Synthetic Core-Skirt Keratoprosthesis.Riau AK1,2, Mondal D2, Yam GH2, Setiawan M2, Liedberg B1,3, Venkatraman SS1, Mehta JS1,2,4,5.ACS Appl Mater Interfaces. 2015 Oct 7;7(39):21690-702. PMID: 26389670


8.

Synergistic effect of ascorbic acid and collagen addition on the increase in type 2 collagen accumulation in cartilage-like MSC sheet.Sato Y, Mera H, Takahashi D, Majima T, Iwasaki N, Wakitani S, Takagi M.Cytotechnology. 2017 Jun;69(3):405-416. PMID: 26572654


9.

Comparison of different cationized proteins as biomaterials for nanoparticle-based ocular gene delivery.Zorzi GK, Párraga JE, Seijo B, Sanchez A.Colloids Surf B Biointerfaces. 2015 Aug 12;135:533-541. PMID: 26298086


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Protective Effects of Soluble Collagen during Ultraviolet-A Crosslinking on Enzyme-Mediated Corneal Ectatic Models.Wang X, Huang Y, Jastaneiah S, Majumdar S, Kang JU, Yiu SC, Stark W, Elisseeff JH.PLoS One. 2015 Sep 1;10(9):e0136999. PMID: 26325407


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Construction of an electrode modified with gallium(III) for voltammetric detection of ovalbumin.Sugawara K, Okusawa M, Takano Y, Kadoya T.Anal Sci. 2014;30(6):649-55. PMID: 24919669


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The promotion of angiogenesis by growth factors integrated with ECM proteins through coiled-coil structures.Assal Y, Mie M, Kobatake E.Biomaterials. 2013 Apr;34(13):3315-23. PMID: 23388150


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Hollow Fiber Module Applied for Effective Proliferation and Harvest of Cultured Chondrocytes.Y. Mori, M. Watanabe, S. Nakagawa, Y. Asawa, S. Nishizawa, K. Okubo, H. Saijo, S. Nagata, Y. Fujihara, T. Takato and K. Hoshi,Materials Sciences and Applications, Vol. 4 No. 8A, 2013, pp. 62-67.


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Effects of hyaluronan oligosaccharides on apoptosis ofhuman gingival fibroblasts.Tanne, Y. ,Tanimoto, K. , Okuma, S. , Kunimatsu, R. , Hirose, N. , Mitsuyoshi, T. and Tanne, K.Open Journal of Stomatology (2013), 3, 19-24.


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The optimization of porous polymeric scaffolds for chondrocyte/atelocollagen based tissue-engineered cartilage.Tanaka Y, Yamaoka H, Nishizawa S, Nagata S, Ogasawara T, Asawa Y, Fujihara Y, Takato T, Hoshi K.Biomaterials. 2010 Jun;31(16):4506-16. PMID: 20206380


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The application of atelocollagen gel in combination with porous scaffolds for cartilage tissue engineering and its suitable conditions.Yamaoka H, Tanaka Y, Nishizawa S, Asawa Y, Takato T, Hoshi K.J Biomed Mater Res A. 2010 Apr;93(1):123-32. PMID: 19536835


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Gastric submucosa as the safer and repeatable site for hepatocyte transplantation.Kakihara N, Takeshita K, Naka S, Ishibashi H.Transplant Proc. 2009 Jan-Feb;41(1):425-8. PMID: 19249571


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Experimental evaluation of a new antithrombogenic stent using ion beam surface modification.Sugita Y, Suzuki Y, Someya K, Ogawa A, Furuhata H, Miyoshi S, Motomura T, Miyamoto H, Igo S, Nosé Y.Artif Organs. 2009 Jun;33(6):456-63. PMID: 19473141


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Effect of interleukins response to ECM-induced acquisition of drug resistance in MCF-7 cells.Ohbayashi M, Yasuda M, Kawakami I, Kohyama N, Kobayashi Y, Yamamoto T.Exp Oncol. 2008 Dec;30(4):276-82. PMID: 19112424


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Feasibility of using a human nucleus pulposus cell line as a cell source in cell transplantation therapy for intervertebral disc degeneration.Iwashina T, Mochida J, Sakai D, Yamamoto Y, Miyazaki T, Ando K, Hotta T.Spine (Phila Pa 1976). 2006 May 15;31(11):1177-86. PMID: 16688029


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Effect of DNA structure on the formation of collagen-DNA complex.Kaya M, Toyama Y, Kubota K, Nodasaka Y, Ochiai M, Nomizu M, Nishi N.Int J Biol Macromol. 2005 Mar;35(1-2):39-46. PMID: 15769514


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Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration.Sakai D, Mochida J, Iwashina T, Watanabe T, Nakai T, Ando K, Hotta T.Spine (Phila Pa 1976). 2005 Nov 1;30(21):2379-87. PMID: 16261113


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Novel bone graft model using bead-cell sheets composed of tricalcium phosphate beads and bone marrow cells.ShunsukeMiyauchi, Katsuko S. Furukawa, Yoshikazu Umezu, Yasuyuki Ozeki, Takashi Ushida, Tetsuya Tateishi.Materials Science and Engineering: C. Volume 24, Issues 6–8, 1 December 2004, Pages 875–879.


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Two-photon microscopic observation of cell-production dynamics in the developing mammalian neocortex in utero.Kawasoe R, Shinoda T, Hattori Y, Nakagawa M, Pham TQ, Tanaka Y, Sagou K, Saito K, Katsuki S, Kotani T, Sano A, Fujimori T, Miyata T.Dev Growth Differ. 2020 Feb;62(2):118-128. PMID: 31943159


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Rapid Photoinduced Single Cell Detachment from Gold Nanoparticle-Embedded Collagen Gels with Low Denaturation Temperature.Kojima C, Nishio M, Nakajima Y, Kawano T, Takatsuka K, Matsumoto A.Polymers (Basel). 2020 Jan 15;12(1). PMID: 31952267


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Hydrostatic pressure promotes endothelial tube formation through aquaporin 1 and Ras-ERK signaling.Yoshino D, Funamoto K, Sato K, Kenry, Sato M, Lim CT.Commun Biol. 2020 Apr 2;3(1):152. PMID: 32242084


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Torula yeast (Candida utilis)‐derived glucosylceramide contributes to dermal elasticity in vitro.Fukunaga, S, Wada, S, Yamashita, M, et al.J Food Biochem. 2019;e12847.


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Nω -(Carboxymethyl)arginine Is One of the Dominant Advanced Glycation End Products in Glycated Collagens and Mouse Tissues.Kinoshita S, Mera K, Ichikawa H, Shimasaki S, Nagai M, Taga Y, Iijima K, Hattori S, Fujiwara Y, Shirakawa JI, Nagai R.Oxid Med Cell Longev. 2019 Sep 10;2019:9073451. PMID: 31583049


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Effect of Mechanical Compression on Invasion Process of Malignant Melanoma Using In Vitro Three-Dimensional Cell Culture Device.Morikura T, Miyata S.Micromachines (Basel). 2019 Sep 30;10(10). PMID: 31575066


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Effect of cell culture density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation.Noda S, Kawashima N, Yamamoto M, Hashimoto K, Nara K, Sekiya I, Okiji T.Sci Rep. 2019 Apr 1;9(1):5430. PMID: 30931957


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Utility of the Teslar Facial Massager for Skin Elasticity and the Mechanism of its Effects. Kazuhisa Maeda, Sakura Koizumi, Taiga Sano, Ayano Yoshimura, HarukaKiriyama and Seina Mimura.Cosmetics 2018, 5(3), 49.


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Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.Nagai N, Ohguchi H, Nakaki R, Matsumura Y, Kanki Y, Sakai J, Aburatani H, Minami T.PLoS Genet. 2018 Nov 30;14(11):e1007826. PMID: 30500808


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Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor.Pham TQ, Kawaue T, Hoshi T, Tanaka Y, Miyata T, Sano A.Sci Rep. 2018 Jul 23;8(1):11085. PMID: 30038295


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Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter.Shinoda T, Nagasaka A, Inoue Y, Higuchi R, Minami Y, Kato K, Suzuki M, Kondo T, Kawaue T, Saito K, Ueno N, Fukazawa Y, Nagayama M, Miura T, Adachi T, Miyata T.PLoS Biol. 2018 Apr 20;16(4):e2004426. PMID: 29677184


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Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis.Watanabe Y, Kawaue T, Miyata T.Development. 2018 Jul 17;145(14). PMID: 29945866


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Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway.Ahn MR, Bae JY, Jeong DH, Takahashi H, Uto Y, Maruta H.Drug DiscovTher. 2017;11(6):300-306. PMID: 29332887


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Dysregulated Collagen Homeostasis by Matrix Stiffening and TGF-β1 in Fibroblasts from Idiopathic Pulmonary Fibrosis Patients: Role of FAK/Akt.Giménez A, Duch P, Puig M, Gabasa M, Xaubet A, Alcaraz J.

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Defined three-dimensional microenvironments boost induction of pluripotency.Caiazzo M, Okawa Y, Ranga A, Piersigilli A, Tabata Y, Lutolf MP.Nat Mater. 2016 Mar;15(3):344-52. PMID: 26752655


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ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs.Lee MH, Goralczyk AG, Kriszt R, Ang XM, Badowski C, Li Y, Summers SA, Toh SA, Yassin MS, Shabbir A, Sheppard A, Raghunath M.Sci Rep. 2016 Feb 17;6:21173. PMID: 26883894


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Dynamics of Tissue-Induced Alignment of Fibrous Extracellular Matrix.Piotrowski-Daspit AS, Nerger BA, Wolf AE, Sundaresan S, Nelson CM.Biophys J. 2017 Aug 8;113(3):702-713. PMID: 28793224


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Increased AGE-RAGE ratio in idiopathic pulmonary fibrosis.Machahua C, Montes-Worboys A, Llatjos R, Escobar I, Dorca J, Molina-Molina M, Vicens-Zygmunt V.Respir Res. 2016 Nov 5;17(1):144.PMID: 27816054


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Differences in the Mechanical Properties of the Developing Cerebral Cortical Proliferative Zone between Mice and Ferrets at both the Tissue and Single-Cell Levels.Nagasaka A, Shinoda T, Kawaue T, Suzuki M, Nagayama K, Matsumoto T, Ueno N, Kawaguchi A and Miyata T.(2016) Front. Cell Dev. Biol. 4:139.


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Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin.Piotrowski-Daspit AS, Tien J, Nelson CM.Integr Biol (Camb). 2016 Mar 14;8(3):319-31. PMID: 26853861


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Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14.Gomes AM, Bhat R, Correia AL, Mott JD, Ilan N, Vlodavsky I, Pavão MS, Bissell M.J Cell Biochem. 2015 Aug;116(8):1668-79. PMID: 25735873


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Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices.Vicens-Zygmunt V, Estany S, Colom A, Montes-Worboys A, Machahua C, Sanabria AJ, Llatjos R, Escobar I, Manresa F, Dorca J, Navajas D, Alcaraz J, Molina-Molina M.Respir Res. 2015 Jul 1;16:82. PMID: 26126411


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Three-dimensional traction force microscopy of engineered epithelial tissues.Piotrowski AS, Varner VD, Gjorevski N, Nelson CM.Methods Mol Biol. 2015;1189:191-206. PMID: 25245695


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Response of Human Skin Fibroblasts to Mechanical Stretch in Wound Healing Process Analyzed Using a Three-Dimensional Culture Model. Kaori Shikano, Keisuke Chiba, Shogo Miyata.Advanced Biomedical Engineering. Vol. 4 (2015) p. 170-178.


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Oxygen diffusion and consumption in extracellular matrix gels: Implications for designing three-dimensional cultures.Colom A, Galgoczy R, Almendros I, Xaubet A, Farré R, Alcaraz J.J Biomed Mater Res A. 2014 Aug;102(8):2776-84. PMID: 24027235


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A spectrophotometer-based diffusivity assay reveals that diffusion hindrance of small molecules in extracellular matrix gels used in 3D cultures is dominated by viscous effects.Galgoczy R, Pastor I, Colom A, Giménez A, Mas F, Alcaraz J.Colloids Surf B Biointerfaces. 2014 Aug 1;120:200-7. PMID: 24916283


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A novel three-dimensional cell culture method to analyze epidermal cell differentiation in vitro.Okugawa Y, Hirai Y.Methods Mol Biol. 2014;1195:183-90. PMID: 24281867


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Tissue-culture light sheet fluorescence microscopy (TC-LSFM) allows long-term imaging of three-dimensional cell cultures under controlled conditions.Pampaloni F, Berge U, Marmaras A, Horvath P, Kroschewski R, Stelzer EH. Integr Biol (Camb). 2014 Oct;6(10):988-98. PMID: 25183478


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Age-related disruption of autophagy in dermal fibroblasts modulates extracellular matrix components.Tashiro K, Shishido M, Fujimoto K, Hirota Y, Yo K, Gomi T, Tanaka Y.BiochemBiophys Res Commun. 2014 Jan 3;443(1):167-72. PMID: 24287182


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The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90β.Correia AL, Mori H, Chen EI, Schmitt FC, Bissell MJ.Genes Dev. 2013 Apr 1;27(7):805-17. PMID: 23592797


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Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ.Development. 2013 Jan;140(2):343-52. PMID: 23250208


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Extracellular epimorphin modulates epidermal differentiation signals mediated by epidermal growth factor receptor.Okugawa Y, Hirai Y.J Dermatol Sci. 2013 Mar;69(3):236-42. PMID: 23219092


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PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.Zhu W, Nelson CM.Dev Biol. 2013 Jul 15;379(2):235-45. PMID: 23665174


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Knockdown of electron transfer flavoprotein β subunit reduced TGF-β-induced α-SMA mRNA expression but not COL1A1 in fibroblast-populated three-dimensional collagen gel cultures.Hirokawa S, Shimanuki T, Kitajima H, Nishimori Y, Shimosaka M.J Dermatol Sci. 2012 Dec;68(3):179-86. PMID: 23068445


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Modulation of invasive phenotype by interstitial pressure-driven convection in aggregates of human breast cancer cells.Tien J, Truslow JG, Nelson CM.PLoS One. 2012;7(9):e45191. PMID: 23028839


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Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening.Alcaraz J, Mori H, Ghajar CM, Brownfield D, Galgoczy R, Bissell MJ.Integr Biol (Camb). 2011 Dec;3(12):1153-66. PMID:21993836


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The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis.Andersen K, Mori H, Fata J, Bascom J, Oyjord T, Mælandsmo GM, Bissell M.Dev Biol. 2011 Apr 15;352(2):181-90. PMID: 21195708


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Role of tumour necrosis factor-α (TNFα) in the functional properties of hyalocytes.Hata Y, Nakao S, Kohno R, Oba K, Kita T, Miura M, Sassa Y, Schering A, Ishibashi T.Br J Ophthalmol. 2011 Feb;95(2):261-5. PMID: 21030411 .


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Identification of ETFB as a candidate protein that participates in the mechanoregulation of fibroblast cell number in collagen gel culture.Hirokawa S, Shimanuki T, Kitajima H, Nishimori Y, Shimosaka M.J Dermatol Sci. 2011 Nov;64(2):119-26. PMID: 21903359


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Novel migrating mouse neural crest cell assay system utilizing P0-Cre/EGFP fluorescent time-lapse imaging.Kawakami M, Umeda M, Nakagata N, Takeo T, Yamamura K.BMC Dev Biol. 2011 Nov 9;11:68. PMID: 22070366


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Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis.Lee K, Gjorevski N, Boghaert E, Radisky DC, Nelson CM.EMBO J. 2011 May 24;30(13):2662-74. PMID: 21610693


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Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture.Pavlovich AL, Boghaert E, Nelson CM.Exp Cell Res. 2011 Aug 1;317(13):1872-84. PMID: 21459084


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Endogenous patterns of mechanical stress are required for branching morphogenesis.Gjorevski N, Nelson CM.Integr Biol (Camb). 2010 Sep;2(9):424-34. PMID: 20717570


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Epimorphin-derived peptide antagonists remedy epidermal parakeratosis triggered by unsaturated fatty acid.Okugawa Y, Bascom JJ, Hirai Y.J Dermatol Sci. 2010 Sep;59(3):176-83. PMID: 20688483


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Madin-Darby canine kidney cells are increased in aerobic glycolysis when cultured on flat and stiff collagen-coated surfaces rather than in physiological 3-D cultures.Pampaloni F, Stelzer EH, Leicht S, Marcello M.Proteomics. 2010 Oct;10(19):3394-413. PMID: 20718008


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Adipose stroma induces branching morphogenesis of engineered epithelial tubules.Pavlovich AL, Manivannan S, Nelson CM.Tissue Eng Part A. 2010 Dec;16(12):3719-26. PMID: 20649458


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Neurotrophic effect of gonadotropin-releasing hormone on neurite extension and neuronal migration of embryonic gonadotropin-releasing hormone neurons in chick olfactory nerve bundle culture.Kanaho Y, Enomoto M, Endo D, Maehiro S, Park MK, Murakami S.J Neurosci Res. 2009 Aug 1;87(10):2237-44. PMID: 19301422


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Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins.Kawahara S, Hata Y, Kita T, Arita R, Miura M, Nakao S, Mochizuki Y, Enaida H, Kagimoto T, Goto Y, Hafezi-Moghadam A, Ishibashi T.Diabetes. 2008 Oct;57(10):2784-93. PMID: 18599521. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17504-9. PMID: 18952846


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Hic-5, an adaptor protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.Kim-Kaneyama JR, Wachi N, Sata M, Enomoto S, Fukabori K, Koh K, Shibanuma M, Nose K.

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Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target.Kita T, Hata Y, Arita R, Kawahara S, Miura M, Nakao S, Mochizuki Y, Enaida H, Goto Y, Shimokawa H, Hafezi-Moghadam A, Ishibashi T.Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17504-9. PMID: 18952846


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Overexpression of extracellular epimorphin leads to impaired epidermal differentiation in HaCaT keratinocytes.Okugawa Y, Hirai Y.J Invest Dermatol. 2008 Aug;128(8):1884-93. PMID: 18273050


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Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis.Hirai Y, Nelson CM, Yamazaki K, Takebe K, Przybylo J, Madden B, Radisky DC.J Cell Sci. 2007 Jun 15;120(Pt 12):2032-43. PMID: 17535848


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Functional characteristics of connective tissue growth factor on vitreoretinal cells.Kita T, Hata Y, Miura M, Kawahara S, Nakao S, Ishibashi T.Diabetes. 2007 May;56(5):1421-8. PMID: 17303801


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Critical role of the Rho-kinase pathway in TGF-beta2-dependent collagen gel contraction by retinal pigment epithelial cells.Miura M, Hata Y, Hirayama K, Kita T, Noda Y, Fujisawa K, Shimokawa H, Ishibashi T.Exp Eye Res. 2006 May;82(5):849-59. PMID: 16310190


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Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S.J Cell Sci. 2006 May 15;119(Pt 10):2107-18. PMID: 16638806


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The effect of hyaluronic acid with different molecular weights on collagen crosslink synthesis in cultured chondrocytes embedded in collagen gels.Abe M, Takahashi M, Nagano A.J Biomed Mater Res A. 2005 Nov 1;75(2):494-9. PMID: 16092114


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Repulsive guidance of axons of spinal sensory neurons in Xenopus laevis embryos: roles of Contactin and notochord-derived chondroitin sulfate proteoglycans.Fujita N, Nagata S.Dev Growth Differ. 2005 Sep;47(7):445-56. PMID: 16179071


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Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16.Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, KohikeH, Komori T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T.BiochemBiophys Res Commun. 2005 Mar 4;328(1):288-91. PMID: 15670782


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Extraocular dorsal signal affects the developmental fate of the optic vesicle and patterns the optic neuroepithelium.Kagiyama Y, Gotouda N, Sakagami K, Yasuda K, Mochii M, Araki M.Dev Growth Differ. 2005 Oct;47(8):523-36. PMID: 16287484


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Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo.Kim-Kaneyama JR, Suzuki W, Ichikawa K, Ohki T, Kohno Y, Sata M, Nose K, Shibanuma M.J Cell Sci. 2005 Mar 1;118(Pt 5):937-49. PMID: 15713747


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Subculture of chondrocytes on a collagen type I-coated substrate with suppressed cellular dedifferentiation.Kino-Oka M, Yashiki S, Ota Y, Mushiaki Y, Sugawara K, Yamamoto T, Takezawa T, Taya M.Tissue Eng. 2005 Mar-Apr;11(3-4):597-608. PMID: 15869436


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Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector.Yokoo N, Saito T, Uesugi M, Kobayashi N, Xin KQ, Okuda K, Mizukami H, Ozawa K, Koshino T.Arthritis Rheum. 2005 Jan;52(1):164-70. PMID: 15641065


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Activin A augments vascular endothelial growth factor activity in promoting branching tubulogenesis in hepatic sinusoidal endothelial cells.Endo D, Kogure K, Hasegawa Y, Maku-uchi M, Kojima I.J Hepatol. 2004 Mar;40(3):399-404. PMID: 15123352


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The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes.Hirayama K, Hata Y, Noda Y, Miura M, Yamanaka I, Shimokawa H, Ishibashi T.Invest Ophthalmol Vis Sci. 2004 Nov;45(11):3896-903. PMID: 15505034


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P311 accelerates nerve regeneration of the axotomized facial nerve.Fujitani M, Yamagishi S, Che YH, Hata K, Kubo T, Ino H, Tohyama M, Yamashita T.J Neurochem. 2004 Nov;91(3):737-44. PMID: 15485502


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Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis.Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC.J Biol Chem. 2004 Nov 26;279(48):50537-54. PMID: 15448146


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Odontoblasts induced from mesenchymal cells of murine dental papillae in three-dimensional cell culture.Kikuchi H, Suzuki K, Sakai N, Yamada S.Cell Tissue Res. 2004 Aug;317(2):173-85. PMID: 15221440


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Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis.Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC.J Biol Chem. 2004 Nov 26;279(48):50537-54. PMID: 15448146


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Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.Minami T, Murakami T, Horiuchi K, Miura M, Noguchi T, Miyazaki J, Hamakubo T, Aird WC, Kodama T.J Biol Chem. 2004 May 14;279(20):20626-35. PMID: 15016828


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Crosslinking of collagen gels by transglutaminase.Orban JM, Wilson LB, Kofroth JA, El-Kurdi MS, Maul TM, Vorp DA.J Biomed Mater Res A. 2004 Mar 15;68(4):756-62. PMID: 14986330


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Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis.Hecht I, Cahalon L, Hershkoviz R, Lahat A, Franitza S, Lider O.Int Immunol. 2003 Jan;15(1):29-38. PMID: 12502723


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Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat.Suzuki Y, Nakagomi S, Namikawa K, Kiryu-Seo S, Inagaki N, Kaibuchi K, Aizawa H, Kikuchi K, Kiyama H.J Neurochem. 2003 Aug;86(4):1042-50. PMID: 12887701


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Effects of growth factors on cell proliferation and matrix synthesis of low-density, primary bovine chondrocytes cultured in collagen I gels.Chaipinyo K, Oakes BW, van Damme MP.J Orthop Res. 2002 Sep;20(5):1070-8. PMID: 12382975


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Growth, antrum formation, and estradiol production of bovine preantral follicles cultured in a serum-free medium.Itoh T, Kacchi M, Abe H, Sendai Y, Hoshi H.Biol Reprod. 2002 Oct;67(4):1099-105. PMID: 12297524


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Tea catechins inhibit angiogenesis in vitro, measured by human endothelial cell growth, migration and tube formation, through inhibition of VEGF receptor binding.Kondo T, Ohta T, Igura K, Hara Y, Kaji K.Cancer Lett. 2002 Jun 28;180(2):139-44. PMID: 12175544


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1.

Cancer cell migration on elongate protrusions of fibroblasts in collagen matrix.Miyazaki K, Oyanagi J, Hoshino D, Togo S, Kumagai H, Miyagi Y.Sci Rep. 2019 Jan 22;9(1):292. PMID: 30670761


2.

IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance.Muraguchi T, Nanba D, Nishimura EK, Tashiro T.J Dermatol Sci. 2019 May;94(2):298-305. PMID: 31122679


3.

Transfection of T-Box Transcription Factor BRACHYURY and SOX2 Synergistically Promote Self-Renewal and Invasive Phenotype in Oral Cancer Cells.Akimoto N, Nakamura K, Hijioka H, Kume K, Matsumura Y, Sugiura T.Int J Mol Sci. 2018 Nov 16;19(11). PMID: 30453543


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Type IV collagen aggregates promote keratinocyte proliferation and formation of epidermal layer in human skin equivalents.Matsuura-Hachiya Y, Arai KY, Muraguchi T, Sasaki T, Nishiyama T. Exp Dermatol. 2018 May;27(5):443-448. PMID: 28266764


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Perfusable and stretchable 3D culture system for skin-equivalent.Mori N, Morimoto Y, Takeuchi S.Biofabrication. 2018 Nov 15;11(1):011001. PMID: 30431022


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Fluid shear stress suppresses ICAM-1-mediated transendothelial migration of leukocytes in coculture model.Sakamoto N, Ueki Y, Oi M, Kiuchi T, Sato M.BiochemBiophys Res Commun. 2018 Jul 20;502(3):403-408. PMID: 29852173


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Skin integrated with perfusable vascular channels on a chip.Mori N, Morimoto Y, Takeuchi S.Biomaterials. 2016 Nov 27;116:48-56. PMID: 27914266


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Hyaluronic acid secretion by synoviocytes alters under cyclic compressive load in contracted collagen gels.Uehara K, Hara M, Matsuo T, Namiki G, Watanabe M, Nomura Y.Cytotechnology. 2015 Jan;67(1):19-26. PMID: 24287612


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Stimulatory effect of fibroblast-derived prostaglandin E2 on keratinocyte stratification in the skin equivalent.Arai KY, Fujioka A, Okamura R, Nishiyama T.Wound Repair Regen. 2014 Nov;22(6):701-11. PMID: 25224163


10.

Repeated folding stress-induced morphological changes in the dermal equivalent.Arai KY, Sugimoto M, Ito K, Ogura Y, Akutsu N, Amano S, Adachi E, Nishiyama T.Skin Res Technol. 2014 Nov;20(4):399-408. PMID: 24506301


11.

Construction of collagen gel scaffolds for mechanical stress analysis.Hara M, Nakashima M, Fujii T, Uehara K, Yokono C, Hashizume R, Nomura Y.BiosciBiotechnolBiochem. 2014 Mar;78(3):458-61. PMID: 25036833


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Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins.Rizqiawan A, Tobiume K, Okui G, Yamamoto K, Shigeishi H, Ono S, Shimasue H, Takechi M, Higashikawa K, Kamata N.BiochemBiophys Res Commun. 2013 Nov 29;441(4):904-10. PMID: 24211210


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Identification of a novel subpopulation of tumor-initiating cells from gemcitabine-resistant pancreatic ductal adenocarcinoma patients.Shimizu K, Chiba S, Hori Y.PLoS One. 2013 Nov 21;8(11):e81283. PMID: 24278411


14.

IL-1beta stimulates activin betaA mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-kappaB pathway, and prostaglandin E2.Arai KY, Ono M, Kudo C, Fujioka A, Okamura R, Nomura Y, Nishiyama T.Endocrinology. 2011 Oct;152(10):3779-90. PMID: 21828177


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Netrin 1 provides a chemoattractive cue for the ventral migration of GnRH neurons in the chick forebrain.Murakami S, Ohki-Hamazaki H, Watanabe K, Ikenaka K, Ono K.J Comp Neurol. 2010 Jun 1;518(11):2019-34. PMID: 20394056


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DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma.Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N.Int J Cancer. 2009 Jun 15;124(12):2837-44. PMID: 19267405


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Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T.J Biol Chem. 2009 Oct 16;284(42):29109-24. PMID: 1967497


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Antibody neutralization of TGF-beta enhances the deterioration of collagen fascicles in a tissue-cultured tendon matrix with ex vivo fibroblast infiltration.Azuma C, Tohyama H, Nakamura H, Kanaya F, Yasuda K.J Biomech. 2007;40(10):2184-90. PMID: 17462658


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Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma.Higashikawa K, Yoneda S, Tobiume K, Taki M, Shigeishi H, Kamata N.Cancer Res. 2007 Oct 1;67(19):9207-13. PMID: 17909026


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Ex vivo infiltration of fibroblasts into the tendon deteriorates the mechanical properties of tendon fascicles but not those of tendon bundles.Ikema Y, Tohyama H, Yamamoto E, Kanaya F, Yasuda K.Clin Biomech (Bristol, Avon). 2007 Jan;22(1):120-6. PMID: 17084002


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TGF-beta and glutathione promote tissue repair in cigarette smoke induced injury.Noguchi C, Umino T, Miyazaki Y, Jinta T, Usui Y, Yoshizawa Y.J Med Dent Sci. 2007 Mar;54(1):109-16. PMID: 19845143


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Middle ear mucosa regeneration by grafting of artificial mucosa.Yaguchi Y, Wada K, Uchimizu H, Tanaka Y, Kojima H, Moriyama H.Acta Otolaryngol. 2007 Oct;127(10):1038-44. PMID: 17851908


23.

Immunohistochemical distribution of heat shock protein 47 (HSP47) in scirrhous carcinoma of the stomach.Hirai K, Kikuchi S, Kurita A, Ohashi S, Adachi E, Matsuoka Y, Nagata K, Watanabe M.Anticancer Res. 2006 Jan-Feb;26(1A):71-8. PMID: 16475681


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In vitro reconstruction of a three-dimensional middle ear mucosal organ and its in vivo transplantation.Wada K, Tanaka Y, Kojima H, Inamatsu M, Yoshizato K, Moriyama H.Acta Otolaryngol. 2006 Aug;126(8):801-10. PMID: 16846921


25.

Growth kinetics and integrin expression of fibroblasts infiltrating devitalised patellar tendons are different from those of intrinsic fibroblasts.Ikema Y, Tohyama H, Nakamura H, Kanaya F, Yasuda K.J Bone Joint Surg Br. 2005 Dec;87(12):1689-93. PMID: 16326888


26.

Creation of a cholesteatoma model using three-dimensional cultured skin equivalents.Tanaka Y, Yaguchi Y, Wada K, Kojima H, Moriyama H.Laryngoscope. 2005 Aug;115(8):1421-7. PMID: 16094116


27.

Characterization of hair follicles induced in implanted, cultured rat keratinocyte sheets.Miyashita H, Hakamata Y, Kobayashi E, Kobayashi K.Exp Dermatol. 2004 Aug;13(8):491-8. PMID: 15265013


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Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels.Berry CC, Shelton JC, Bader DL, Lee DA.Tissue Eng. 2003 Aug;9(4):613-24. PMID: 13678440


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In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin.Kikuchi K, Kishino A, Konishi O, Kumagai K, Hosotani N, Saji I, Nakayama C, Kimura T.J Biol Chem. 2003 Oct 31;278(44):42985-91. PMID: 12933805


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Colonization of in vitro-formed cervical human papillomavirus- associated (pre)neoplastic lesions with dendritic cells: role of granulocyte/macrophage colony-stimulating factor.Hubert P, van den Brüle F, Giannini SL, Franzen-Detrooz E, Boniver J, Delvenne P.Am J Pathol. 1999 Mar;154(3):775-84. PMID: 10079255


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Effects of microgravity on c-fos gene expression in osteoblast-like MC3T3-E1 cells.Sato A, Hamazaki T, Oomura T, Osada H, Kakeya M, Watanabe M, Nakamura T, Nakamura Y, Koshikawa N, Yoshizaki I, Aizawa S, Yoda S, Ogiso A, Takaoki M, Kohno Y, Tanaka H.Adv Space Res. 1999;24(6):807-13. PMID: 11542626


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A reconstituted skin:Dermal-epidermal interactions in collagenolysis and cell morphology.YoshizatoK,NishikawaA,Taira T. Biomed Res, 7(4):219-31. 1986.

I-AC培养器材包被

1.

Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet.Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H.Tissue Eng Part C Methods. 2020 Mar;26(3):170-179. PMID: 32186996


2.

The reduced susceptibility of mouse keratinocytes to retinoic acid may be involved in the keratinization of oral and esophageal mucosal epithelium.Miyazono S, Otani T, Ogata K, Kitagawa N, Iida H, Inai Y, Matsuura T, Inai T.Histochem Cell Biol. 2020 Jan 31. [Epub ahead of print] PMID: 32006103


3.

Biomechanical analysis of the mechanical environment of the cell nucleus in serum starvation-induced vascular smooth muscle cell differentiation.Kazuaki NAGAYAMA.Journal of Biomechanical Science and Engineering, Vol.14, No.4 (2019)


4.

Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation.Takimoto A, Kokubu C, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y, Shukunami C.Sci Rep. 2019 Mar 14;9(1):4605. PMID: 30872687


5.

Endovascular trophoblast expresses CD59 to evade complement-dependent cytotoxicity.Ueda M, Sato Y, Horie A, Tani H, Miyazaki Y, Okunomiya A, Matsumoto H, Hamanishi J, Kondoh E, Mandai M.Mol Cell Endocrinol. 2019 Apr 11. pii: S0303-7207(19)30106-6. PMID: 30981734


6.

CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway.Yasui H1,2, Kajiyama H3, Tamauchi S1, Suzuki S1, Peng Y1, Yoshikawa N1, Sugiyama M1, Nakamura K1, Kikkawa F1.Clin Exp Metastasis. 2020 Feb;37(1):145-158. PMID: 31541326


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Reciprocal expression of Slug and Snail in human oral cancer cells.Nakamura R, Ishii H, Endo K, Hotta A, Fujii E, Miyazawa K, Saitoh M.PLoS One. 2018 Jul 3;13(7):e0199442. PMID: 29969465


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MicroRNA 148a-3p promotes Thrombospondin-4 expression and enhances angiogenesis during tendinopathy development by inhibiting Krüppel-like factor 6.Ge H, Shrestha A, Liu C, Wu P, Cheng B.BiochemBiophys Res Commun. 2018 Jul 12;502(2):276-282. PMID: 29807011 PMID: 29807011


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Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates.Kikkawa Y, Enomoto-Okawa Y, Fujiyama A, Fukuhara T, Harashima N, Sugawara Y, Negishi Y, Katagiri F, Hozumi K, Nomizu M, Ito Y.Sci Rep. 2018 Apr 26;8(1):6612. PMID: 29700410.


10.

Enhanced survival and insulin secretion of insulinoma cell aggregates by incorporating gelatin hydrogel microspheres.Kanako Inoo, Hiroto Bando, Yasuhiko Tabata.Regenerative Therapy, Volume 8, June 2018, Pages 29-37.


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Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.Shukunami C, Takimoto A, Nishizaki Y, Yoshimoto Y, Tanaka S, Miura S, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y.Sci Rep. 2018 Feb 16;8(1):3155. PMID: 29453333


12.

Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes.Hirata H, Samsonov M, Sokabe M.Sci Rep. 2017 Apr 13;7:46326. PMID: 28406163


13.

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes.Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sudhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH, Suzuki M, Raghunath M.Sci Rep. 2017 May 3;7(1):1383. PMID: 28469146


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The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration.Matsumura K, Kawasaki Y, Miyamoto M, Kamoshida Y, Nakamura J, Negishi L, Suda S, Akiyama T.Oncogene. 2017 Mar 2;36(9):1191-1199. PMID: 27797375


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Bio-active molecules modified surfaces enhanced mesenchymal stem cell adhesion and proliferation.Mobasseri R, Tian L, Soleimani M, Ramakrishna S, Naderi-Manesh H.BiochemBiophys Res Commun. 2017 Jan 29;483(1):312-317. PMID: 28025144


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Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma.Mukudai Y, Zhang M, Shiogama S, Kondo S, Ito C, Motohashi H, Kato K, Fujii M, Shintani S, Shigemori H, Yazawa K, Shirota T.Evid Based Complement Alternat Med. 2016;2016:6087213. PMID: 2729346

2

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Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction.Nowell CS, Odermatt PD, Azzolin L, Hohnel S, Wagner EF, Fantner GE, Lutolf MP, Barrandon Y, Piccolo S, Radtke F.Nat Cell Biol. 2016 Feb;18(2):168-80. PMID: 26689676


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Ammonia-induced energy disorders interfere with bilirubin metabolism in hepatocytes.Wang Q, Wang Y, Yu Z, Li D, Jia B, Li J, Guan K, Zhou Y, Chen Y, Kan Q.Arch BiochemBiophys. 2014 Aug;555-556:16-22. PMID: 24878366


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Isolation of mesenchymal stem cells from human dermis.Soma T, Kishimoto J, Fisher D.Methods Mol Biol. 2013;989:265-74. PMID: 23483401


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Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene.Hori T, Jin L, Fujii A, Furihata T, Nagahara Y, Chiba K, Hosokawa M.Xenobiotica. 2012 Jul;42(7):614-23. PMID:22235919


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Fibroblast Growth Factor Receptor 2 IIIc as a Therapeutic Target for Colorectal Cancer Cells.Matsuda Y, Hagio M, Seya T, Ishiwata T.Mol Cancer Ther. 2012 Sep;11(9):2010-20. PMID:22778155


22.

Effect of preservation conditions of collagen substrate on its fibril formation and rabbit chondrocyte morphology.Nadzir MM, Kino-oka M, Sugawara K, Taya M.J BiosciBioeng. 2012 Sep;114(3):360-3. PMID: 22677065


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Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N.Mol Biol Cell. 2012 Aug;23(15):2845-55. PMID:22696678


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α1- and α5-containing Laminins Regulate the Development of Bile Ducts via β1 Integrin Signals.Tanimizu N, Kikkawa Y, Mitaka T, Miyajima A.J Biol Chem. 2012 Aug 17;287(34):28586-97. PMID:22761447


25.

Modulation of cytochrome P450 gene expression in primary hepatocytes on various artificial extracellular matrices.Adachi T, Goto M, Cho CS, Akaike T.BiochemBiophys Res Commun. 2011 Oct 7;413(4):577-81. PMID: 21930114


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Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancer.Matsuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng WX, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z.Cancer Lett. 2011 Oct 28;309(2):209-19. PMID: 21745712


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Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.Ogimura E, Sekine S, Horie T.BiochemBiophys Res Commun. 2011 Dec 16;416(3-4):313-7. PMID: 22108051


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Combined stimulation with cyclic stretching and hypoxia increases production of matrix metalloproteinase-9 and cytokines by macrophages.Oya K, Sakamoto N, Ohashi T, Sato M.BiochemBiophys Res Commun. 2011 Sep 9;412(4):678-82. PMID: 21867689


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Cell behavior on protein matrices containing laminin α1 peptide AG73.Yamada Y, Katagiri F, Hozumi K, Kikkawa Y, Nomizu M.Biomaterials. 2011 Jul;32(19):4327-35. PMID: 21420730


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Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells.Ishiwata T, Yamamoto T, Kawahara K, Kawamoto Y, Matsuda Y, Ishiwata S, Naito Z.Exp Mol Pathol. 2010 Jun;88(3):363-70. PMID: 20138170


31.

Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow?Jung SM, Sonoda M, Tsuji K, Jimi A, Nomura S, Kanaji T, Moroi M.Platelets. 2010;21(2):101-11. PMID: 20063990


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The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.Kawasaki Y, Jigami T, Furukawa S, Sagara M, Echizen K, Shibata Y, Sato R, Akiyama T.J Biol Chem. 2010 Jan 8;285(2):1199-207. PMID: 19897489


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Atmospheric scanning electron microscope observes cells and tissues in open medium through silicon nitride film.Nishiyama H, Suga M, Ogura T, Maruyama Y, Koizumi M, Mio K, Kitamura S, Sato C.J Struct Biol. 2010 Nov;172(2):191-202. PMID: 20723603


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Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes.Sasai N, Agata N, Inoue-Miyazu M, Kawakami K, Kobayashi K, Sokabe M, Hayakawa K.Muscle Nerve. 2010 Jan;41(1):100-6. PMID: 19768770


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Expression of Notch signalling-related genes in normal and differentiating rat dental pulp cells.Sun H, Kawashima N, Xu J, Takahashi S, Suda H.Aust Endod J. 2010 Aug;36(2):54-8. PMID: 20666749


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Natalizumab has no direct biological effect on JC virus infectivity in permissive human neural cell lines.Suzuki T, Yamanouchi S, Sunden Y, Orba Y, Kimura T, Sawa H.J Med Virol. 2010 Jul;82(7):1229-35. PMID: 20513089


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Construction of multifunctional proteins for tissue engineering: epidermal growth factor with collagen binding and cell adhesive activities.HannachiImen E, Nakamura M, Mie M, Kobatake E.J Biotechnol. 2009 Jan 1;139(1):19-25. PMID: 18984018


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Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase.Kawasaki Y, Tsuji S, Sagara M, Echizen K, Shibata Y, Akiyama T.J Biol Chem. 2009 Aug 14;284(33):22436-43. PMID: 19525225


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A collagen-coated surface enables quantitative evaluation of morphological behaviors of rabbit chondrocytes relating to cell differentiation in an early culture phase.Ali BaradarKhoshfetrata, Masahiro Kino-okaa, KatsuraSugawarab and Masahito TayaBiochemical Engineering Journal Volume 45, Issue 1, 1 June 2009, Pages 60-68


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ATP Release from Cultured Endothelial Cells and Intercellular Calcium Signaling during Shear Stress Exposure.Kudo Susumu, Hosoe Kaoru, Hosobuchi Makoto, Kawasaki Naoto, Tanishita KazuoJournal of Biomechanical Science and Engineering 4(2), 274-285, 2009.


41.

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments.LaBarge MA, Nelson CM, Villadsen R, Fridriksdottir A, Ruth JR, Stampfer MR, Petersen OW, Bissell MJ.Integr Biol (Camb). 2009 Jan;1(1):70-9. PMID: 20023793


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Contribution of the LIM domain and nebulin-repeats to the interaction of Lasp-2 with actin filaments and focal adhesions.Nakagawa H, Suzuki H, Machida S, Suzuki J, Ohashi K, Jin M, Miyamoto S, Terasaki AG.PLoS One. 2009 Oct 23;4(10):e7530. PMID: 19851499


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Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T.Oncogene. 2009 Mar 12;28(10):1357-65. PMID: 19151759


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Detection of mRNA in single living cells using AFM nanoprobes.Uehara H, Ikai A, Osada T.Methods Mol Biol. 2009;544:599-608. PMID: 19488726


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Expansion and characterization of adipose tissue-derived stromal cells cultured with low serum medium.Hattori H, Nogami Y, Tanaka T, Amano Y, Fukuda K, Kishimoto S, Kanatani Y, Nakamura S, Takase B, Ishihara M.J Biomed Mater Res B Appl Biomater. 2008 Oct;87(1):229-36. PMID: 18496860


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Different regulation of hepatocyte behaviors between natural extracellular matrices and synthetic extracellular matrices by hepatocyte growth factor.Hoshiba T, Wakejima M, Cho CS, Shiota G, Akaike T.J Biomed Mater Res A. 2008 Apr;85(1):228-35. PMID: 17688272


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Ectopic transplantation of hepatocyte sheets fabricated with temperature-responsive culture dishes.Kano K, Yamato M, Okano T.Hepatol Res. 2008;38(11):1140-7. PMID: 18513332


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Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells.Kuriyama I, Mizuno T, Fukudome K, Kuramochi K, Tsubaki K, Usui T, Imamoto N, Sakaguchi K, Sugawara F, Yoshida H, Mizushina Y.Molecules. 2008 Dec 1;13(12):2948-61. PMID: 19043348


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Primary hepatocyte survival on non-integrin-recognizable matrices without the activation of Akt signaling.Hoshiba T, Nagahara H, Cho CS, Tagawa Y, Akaike T.Biomaterials. 2007 Feb;28(6):1093-104. PMID: 17081603


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Epidermal growth factor signaling for matrix-dependent cell proliferation and differentiation in primary cultured hepatocytes.Kim SH, Akaike T.Tissue Eng. 2007 Mar;13(3):601-9. PMID: 17518606


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Comparison of basal gene expression and induction of CYP3As in HepG2 and human fetal liver cells.Maruyama M, Matsunaga T, Harada E, Ohmori S.Biol Pharm Bull. 2007 Nov;30(11):2091-7. PMID: 17978482


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A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion.Moroi M, Jung SM.J ThrombHaemost. 2007 Apr;5(4):797-803. PMID: 17408410


53.

Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation.Nakajima M, Ishimuro T, Kato K, Ko IK, Hirata I, Arima Y, Iwata H.Biomaterials. 2007 Feb;28(6):1048-60. PMID: 17081602


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Identification and characterization of GSRP-56, a novel Golgi-localized spectrin repeat-containing protein.Kobayashi Y, Katanosaka Y, Iwata Y, Matsuoka M, Shigekawa M, Wakabayashi S.Exp Cell Res. 2006 Oct 1;312(16):3152-64. PMID: 16875688


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Murine metanephric mesenchyme possesses characteristics of vascular endothelial cells in vitro.Usui J, Yamada R, Kanemoto K, Koyama A, Nagata M.Nephron Exp Nephrol. 2006;102(3-4):e93-8. PMID: 16282704


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Association of expression of receptor for advanced glycation end products and invasive activity of oral squamous cell carcinoma.Bhawal UK, Ozaki Y, Nishimura M, Sugiyama M, Sasahira T, Nomura Y, Sato F, Fujimoto K, Sasaki N, Ikeda MA, Tsuji K, Kuniyasu H, Kato Y.Oncology. 2005;69(3):246-55. PMID: 16127291


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Fibrous component of the blastocoelic extracellular matrix shapes epithelia in concert with mesenchyme cells in starfish embryos.Kaneko H, Okai M, Murabe N, Shimizu T, Ikegami S, Dan-Sohkawa M.Dev Dyn. 2005 Apr;232(4):915-27. PMID: 15739228


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Differential growth properties of normal and malignant esophageal epithelial cells: a possible cross talk between transforming growth factor-beta1 and epidermal growth factor signaling.Katayama M, Shoji M, Satomi S.Tohoku J Exp Med. 2005 May;206(1):61-71. PMID: 15802876


59.

Process design of chondrocyte cultures with monolayer growth for cell expansion and subsequent three-dimensional growth for production of cultured cartilage.Kino-oka M, Maeda Y, Ota Y, Yashiki S, Sugawara K, Yamamoto T, Taya M.J BiosciBioeng. 2005 Jul;100(1):67-76. PMID: 16233853


60.

Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome.Koshikawa M, Mukoyama M, Mori K, Suganami T, Sawai K, Yoshioka T, Nagae T, Yokoi H, Kawachi H, Shimizu F, Sugawara A, Nakao K.J Am Soc Nephrol. 2005 Sep;16(9):2690-701. PMID: 15987752


61.

Effect of fluid force on vascular cell function.Kudo S, Yamaguchi R, Ikeda M, Tanishita K.J PhysiolAnthropol Appl Human Sci. 2005 Jul;24(4):459-61. PMID: 16079597


62.

Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S, Itoh A, Funata N, Schreiber SL, Yoshida M, Toi M.Oncogene. 2005 Jun 30;24(28):4531-9. PMID: 15806142


63.

Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries.Sato Y, Fujiwara H, Zeng BX, Higuchi T, Yoshioka S, Fujii S.Blood. 2005 Jul 15;106(2):428-35. PMID: 15797992


64.

Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4-5 domain of alpha3 chain.Tsubota Y, Yasuda C, Kariya Y, Ogawa T, Hirosaki T, Mizushima H, Miyazaki K.J Biol Chem. 2005 Apr 15;280(15):14370-7. PMID: 15695818


65.

Genotype 2a hepatitis C virus subgenomic replicon can replicate in HepG2 and IMY-N9 cells.Date T, Kato T, Miyamoto M, Zhao Z, Yasui K, Mizokami M, Wakita T.J Biol Chem. 2004 May 21;279(21):22371-6. PMID: 14990575


66.

Astrocytes express type VIII collagen during the repair process of brain cold injury.Hirano S, Yonezawa T, Hasegawa H, Hattori S, Greenhill NS, Davis PF, Sage EH, Ninomiya Y.BiochemBiophys Res Commun. 2004 Apr 30;317(2):437-43. PMID: 15063777


67.

Expression of lysosomal protective protein/cathepsin A in a stably transformed human neuroblastoma cell line during bi-directional differentiation into neuronal and Schwannian cells.Itoh K, Satoh Y, Kadota Y, Oheda Y, Kuwahara J, Shimmoto M, Sakuraba H.Neurochem Int. 2004 May;44(6):447-57. PMID: 14687610


68.

Preparation of lactose-silk fibroin conjugates and their application as a scaffold for hepatocyte attachment.Gotoh Y, Niimi S, Hayakawa T, Miyashita T.Biomaterials. 2004 Mar;25(6):1131-40. PMID: 14615179


69.

Antithrombogenicity of cultured endothelial cells exposed to blood under stagnant flow conditions.Makoto Kaibara, TasukuYotoriyama, Ryutaro Himeno.Journal of Japanese Society of Biorheology. Vol. 18 (2004) No. 1 p. 52-59.


70.

The basement membrane protein laminin-5 acts as a soluble cell motility factor.Kariya Y, Miyazaki K.Exp Cell Res. 2004 Jul 15;297(2):508-20. PMID: 15212952


71.

N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor.Kawamura K, Takano K, Suetsugu S, Kurisu S, Yamazaki D, Miki H, Takenawa T, Endo T.J Biol Chem. 2004 Dec 24;279(52):54862-71. PMID: 15496413


72.

Hepatocyte behavior on synthetic glycopolymer matrix: inhibitory effect of receptor-ligand binding on hepatocyte spreading.Kim SH, Hoshiba T, Akaike T.Biomaterials. 2004 May;25(10):1813-23. PMID: 14738845


73.

Microbial serine carboxypeptidase inhibitors–comparative analysis of actions on homologous enzymes derived from man, yeast and wheat.Satoh Y, Kadota Y, Oheda Y, Kuwahara J, Aikawa S, Matsuzawa F, Doi H, Aoyagi T, Sakuraba H, Itoh K.J Antibiot (Tokyo). 2004 May;57(5):316-25. PMID: 15303492


74.

Human amniotic epithelial cells possess hepatocyte-like characteristics and functions.Takashima S, Ise H, Zhao P, Akaike T, Nikaido T.Cell Struct Funct. 2004 Jun;29(3):73-84. PMID: 15528839


75.

Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.Pang T, Wakabayashi S, Shigekawa M.J Biol Chem. 2002 Nov 15;277(46):43771-7. PMID: 12226101


76.

Acquisition of susceptibility to hepatitis C virus replication in HepG2 cells by fusion with primary human hepatocytes: establishment of a quantitative assay for hepatitis C virus infectivity in a cell culture system.Ito T, Yasui K, Mukaigawa J, Katsume A, Kohara M, Mitamura K.Hepatology. 2001 Sep;34(3):566-72. PMID: 11526543


77.

Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death.Imaizumi K, Tsuda M, Imai Y, Wanaka A, Takagi T, Tohyama M.J Biol Chem. 1997 Jul 25;272(30):18842-8. PMID: 9228060


78.

Possible involvement of a novel protease in neurite outgrowth of PC12 cells.Saito Y, Tsubuki S, Ito H, Kawashima S.Neurosci Res Suppl. 1990;13:S97-101. PMID: 2088345

I-AC支架制备/包被

1.

Cell fibers promote proliferation of co-cultured cells on a dish.Shima A, Itou A, Takeuchi S.Sci Rep. 2020 Jan 14;10(1):288. PMID: 31937888


2.

Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly.Kurashina Y, Sato R, Onoe H.APL Bioeng. 2019 Nov 13;3(4):046101. PMID: 31737859


3.

A novel micro-grooved collagen substrate for inducing vascular smooth muscle differentiation through cell tissue arrangement and nucleus remodeling.Nagayama K, Uchida K, Sato A.J Mech Behav Biomed Mater. 2019 Feb;90:295-305. PMID: 30396043


4.

Microfluidic vascular-bed devices for vascularized 3D tissue engineering: tissue engineering on a chip.Takehara H, Sakaguchi K, Sekine H, Okano T, Shimizu T.Biomed Microdevices. 2019 Dec 20;22(1):9. PMID: 31863202


5.

Temporal Observation of Adipocyte Microfiber Using Anchoring Device.Yokomizo A, Morimoto Y, Nishimura K, Takeuchi S.Micromachines (Basel). 2019 May 29;10(6). PMID: 31146491


6.

VEGF delivery by smart polymeric PNIPAM nanoparticles affects both osteogenic and angiogenic capacities of human bone marrow stem cells.Adibfar A, Amoabediny G, BaghabanEslaminejad M, Mohamadi J, Bagheri F, ZandiehDoulabi B.Mater Sci Eng C Mater Biol Appl. 2018 Dec 1;93:790-799. PMID: 30274113


7.

Double-layer perfusable collagen microtube device for heterogeneous cell culture.Itai S, Tajima H, Onoe H.Biofabrication. 2018 Nov 30;11(1):015010. PMID: 30499456


8.

An allogeneic 'off the shelf' therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells.O'Rourke C, Day AGE, Murray-Dunning C, Thanabalasundaram L, Cowan J, Stevanato L, Grace N, Cameron G, Drake RAL, Sinden J, Phillips JB.Sci Rep. 2018 Feb 13;8(1):2951. PMID: 29440680


9.

Anchorage-dependent cell expansion in fiber-shaped microcarrier aggregates.Ikeda K, Takeuchi S.Biotechnol Prog. 2019 Mar;35(2):e2755. PMID: 30468323.


10.

Optimal biomaterials for tracheal epithelial grafts: an in vitro systematic comparative analysis.Varma R, Aoki FG, Soon K, Karoubi G, Waddell TK.Acta Biomater. 2018 Nov;81:146-157. PMID: 30268918


11.

The Effect of Hypothermic and Cryogenic Preservation on Engineered Neural Tissue.Day AGE, Bhangra KS, Murray-Dunning C, Stevanato L, Phillips J.Tissue Eng Part C Methods. 2017 Oct;23(10):575-582. PMID: 28877649


12.

Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary.Yoshida K, Onoe H.Sci Rep. 2017 Apr 5;7:45987. doi: 10.1038/srep45987. PMID: 28378803


13.

Compartmentalized Spherical Collagen Microparticles for Anisotropic Cell Culture Microenvironments.Yoshida S, Takinoue M, Onoe H.Adv Healthc Mater. 2017 Apr;6(8). PMID: 28322015


14.

Collagen Vitrigels with Low-fibril Density Enhance Human Embryonic Stem. Cell-Derived Retinal Pigment Epithelial Cell Maturation.Wang X, Maruotti J, Majumdar S, Roman J, Mao HQ, Zack D, Elisseeff J.J Tissue Eng Regen Med. 2018 Mar;12(3):821-829. PMID: 29049869


15.

3D Tissue Formation of Unilocular Adipocytes in Hydrogel Microfibers.Hsiao AY, Okitsu T, Teramae H, Takeuchi S. Adv Healthc Mater. 2016 Mar 9;5(5):548-56. PMID: 26680212


16.

Influence of collagen source on fibrillar architecture and properties of vitrified collagen membranes.Majumdar S, Guo Q, Garza-Madrid M, Calderon-Colon X, Duan D, Carbajal P, Schein O, Trexler M, Elisseeff J.J Biomed Mater Res B Appl Biomater. 2016 Feb;104(2):300-7. PMID: 25766399


17.

An electrically resistive sheet of glial cells for amplifying signals of neuronal extracellular recordings.Matsumura R, Yamamoto H, Niwano M, Hirano-Iwata A.Appl Phys Lett. 2016 Jan 11;108(2):023701.PMID: 27703279


18.

Vessel-like channels supported by poly-l-lysine tubes.Mori N, Morimoto Y, Takeuchi S.J BiosciBioeng. 2016 Dec;122(6):753-757 PMID: 27323931


19.

Formation of Highly Aligned Collagen Nanofibers by Continuous Cyclic Stretch of a Collagen Hydrogel Sheet.Nam , Lee WC, Takeuchi S.MacromolBiosci. 2016 Jul;16(7):995-1000. PMID: 27136124


20.

Regeneration of corneal epithelium utilizing a collagen vitrigel membrane in rabbit models for corneal stromal wound and limbal stem cell deficiency.Chae JJ, Ambrose WM, Espinoza FA, Mulreany DG, Ng S, Takezawa T, Trexler MM, Schein OD, Chuck RS, Elisseeff JH.


21.

Acta Ophthalmol. 2015 Feb;93(1):e57-66. PMID: 25495158. Smooth muscle-like tissue constructs with circumferentially oriented cells formed by the cell fiber technology.Hsiao AY, Okitsu T, Onoe H, Kiyosawa M, Teramae H, Iwanaga S, Kazama T, Matsumoto T, Takeuchi S.PLoS One. 2015 Mar 3;10(3):e0119010. PMID: 25734774


22.

Optimization of optical and mechanical properties of Real Architecture for 3-Dimensional Tissue equivalents: Towards treatment of limbal epithelial stem cell deficiency.Massie I, Kureshi AK, Schrader S, Shortt AJ, Daniels JT.Acta Biomater. 2015 Sep 15;24:241-50. PMID: 2609235

2

23.

Fabrication of fibrillized collagen microspheres with the microstructure resembling an extracellular matrix.Matsuhashi A, Nam K, Kimura T, Kishida A.Soft Matter. 2015 Apr 14;11(14):2844-51. PMID: 25708876


24.

Preparation Fibrillized Collagen-Glycosaminoglycan Complex Matrix Using Fibrillogenesis.Nam, K., Kimura, T. and Kishida, A.MacromolSymp. 2015 358:95–105.


25.

Neural stem/progenitor cell-laden microfibers promote transplant survival in a mouse transected spinal cord injury model.Sugai K, Nishimura S, Kato-Negishi M, Onoe H, Iwanaga S, Toyama Y, Matsumoto M, Takeuchi S, Okano H, Nakamura M.J Neurosci Res. 2015 Dec;93(12):1826-38. PMID: 26301451


26.

Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness.Tanahashi K, Natsume A, Ohka F, Motomura K, Alim A, Tanaka I, Senga T, Harada I, Fukuyama R, Sumiyoshi N, Sekido Y, Wakabayashi T.J Neuropathol Exp Neurol. 2015 Jul;74(7):704-9. PMID: 26049897


27.

Application of a collagen-based membrane and chondroitin sulfate-based hydrogel adhesive for the potential repair of severe ocular surface injuries.Chae JJ, Mulreany DG, Guo Q, Lu Q, Choi JS, Strehin I, Espinoza FA, Schein O, Trexler MM, Bower KS, Elisseeff JH.Mil Med. 2014 Jun;179(6):686-94. PMID: 24902138


28.

Design and construction of an equibiaxial cell stretching system that is improved for biochemical analysis.Ursekar CP, Teo SK, Hirata H, Harada I, Chiam KH, Sawada Y.PLoS One. 2014 Mar 13;9(3):e90665. PMID: 24626190


29.

Banded structures in collagen vitrigels for corneal injury repair.Xia Z, Calderón-Colón X, McCally R, Maranchi J, Rong L, Hsiao B, Elisseeff J, Trexler M.Acta Biomater. 2014 Aug;10(8):3615-9. PMID: 24859294


30.

Vitrified collagen-based conjunctival equivalent for ocular surface reconstruction.Zhou H, Lu Q, Guo Q, Chae J, Fan X, Elisseeff JH, Grant MP.Biomaterials. 2014 Aug;35(26):7398-406. PMID: 24933512


31.

Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair.Guo Q, Phillip JM, Majumdar S, Wu PH, Chen J, Calderón-Colón X, Schein O, Smith BJ, Trexler MM, Wirtz D, Elisseeff JH.Biomaterials. 2013 Dec;34(37):9365-72. PMID: 24041426


32.

Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions.Ishihara S, Yasuda M, Harada I, Mizutani T, Kawabata K, Haga H.Exp Cell Res. 2013 Nov 15;319(19):2916-27. PMID: 24113574


33.

Metre-long cell-laden microfibres exhibit tissue morphologies and functions. Onoe H, Okitsu T, Itou A, Kato-Negishi M, Gojo R, Kiriya D, Sato K, Miura S, Iwanaga S, Kuribayashi-Shigetomi K, Matsunaga YT, Shimoyama Y, Takeuchi S. Nat Mater. 2013 Jun;12(6):584-90. PMID: 23542870


34.

Regenerative process of tracheal epithelium using a collagen vitrigel sponge scaffold.Tani A, Tada Y, Takezawa T, Wada I, Imaizumi M, Nomoto Y, Nomoto M, Omori K.Laryngoscope. 2013 Jun;123(6):1469-73. PMID: 23625522


35.

Cellular response to substrate rigidity is governed by either stress or strain.Yip AK, Iwasaki K, Ursekar C, Machiyama H, Saxena M, Chen H, Harada I, Chiam KH, Sawada Y.Biophys J. 2013 Jan 8;104(1):19-29. PMID: 23332055


36.

Structure and properties of collagen vitrigel membranes for ocular repair and regeneration applications.Calderón-Colón X, Xia Z, Breidenich JL, Mulreany DG, Guo Q, Uy OM, Tiffany JE, Freund DE, McCally RL, Schein OD, Elisseeff JH, Trexler MM.Biomaterials. 2012 Nov;33(33):8286-95. PMID: 22920579


37.

Local mechanical stimulation of mardin-darby canine kidney cell sheets on temperature-responsive hydrogel.Harada I, Yanagisawa S, Iwasaki K, Cho CS, Akaike T.Int J Mol Sci. 2012;13(1):1095-108. PMID:22312306


38.

Hybrid scaffolds composed of hyaluronic acid and collagen for cartilage regeneration.Hyun Jung Kim, KabKeun Kim, Il Kyu Park, Baek Sun Choi, Jae Ho Kim and Moon Suk Kim. Tissue Engineering and Regenerative Medicine. Volume 9, Number 2 (2012), 57-62.


39.

Fabrication of a heterostructural fibrillated collagen matrix for the regeneration of soft tissue function.Kwangwoo Nam, Yuuki Sakai, Yoshihide Hashimoto, Tsuyoshi Kimura and Akio Kishida. Soft Matter, 2012, 8, 472-480.


40.

Matrix compliance and RhoA direct the differentiation of mammary progenitor cells.Lui C, Lee K, Nelson CM.Biomech Model Mechanobiol. 2012 Nov;11(8):1241-9. PMID: 22161021


41.

Regulation of growth factors-associated cell migration by C-phycocyanin scaffold in dermal wound healing.Madhyastha H, Madhyastha R, Nakajima Y, Omura S, Maruyama M.Clin Exp Pharmacol Physiol. 2012 Jan;39(1):13-9. PMID:21995435


42.

Heterofunctional nanosheet controlling cell adhesion properties by collagen coating.Niwa D, Fujie T, Lang T, Goda N, Takeoka S.J Biomater Appl. 2012 Aug;27(2):131-41. PMID: 21343215


43..

Thermal denaturation of type I collagen vitrified gels.Zhiyong Xia, Xiomara Calderon-Colona, Morgana Trexlera, Jennifer Elisseeffb, QiongyuGuob. ThermochimicaActaVolume 527, 10 January 2012, Pages 172–179.


44.

Engineering a collagen matrix that replicates the biological properties of native extracellular matrix.

Nam K, Sakai Y, Funamoto S, Kimura T, Kishida A.J Biomater Sci Polym Ed. 2011;22(15):1963-82. PMID: 20961498


45.

A nano-fibrous assembly of collagen–hyaluronic acid for controlling cell-adhesive properties.ToshinoriFujie, ShoFurutate, Daisuke Niwaa and Shinji Takeoka. Soft Matter, 2010,6, 4672-4676


46.

Preparation of a collagen/polymer hybrid gel designed for tissue membranes. Part I: controlling the polymer-collagen cross-linking process using an ethanol/water co-solvent.Nam K, Kimura T, Funamoto S, Kishida A.Acta Biomater. 2010 Feb;6(2):403-8. PMID: 19531383


47.

Preparation of a collagen/polymer hybrid gel for tissue membranes. Part II: in vitro and in vivo biological properties of the collagen gels.Nam K, Kimura T, Funamoto S, Kishida A.Acta Biomater. 2010 Feb;6(2):409-17. PMID: 19539060


48.

Micro 3D Culture System using Hyaluronan-Collagen Capsule for Skeletal Muscle-Derived Stem Cells.Tono-Okada K, Okada Y, Masuda Y, Akio Hoshi, Akira Akatsuka, Akira Teramoto, Koji Abe and Tetsuro Tamaki.Open Tissue Eng Regen Med J, 2010, 3, 18-27.


49.

Construction and Biofunction of 3-Dimensional Self-assembly Collagen Nanostructure on PLLA Substrate.Shouhong Xu, Aiping Liu, Xiaoxiao Lin, Honglai Liu and MasakastuYonese. Chin J Chem. 2010 28: 1565–1574.


50.

Cryopreservation in situ of cell monolayers on collagen vitrigel membrane culture substrata: ready-to-use preparation of primary hepatocytes and ES cells.Miyamoto Y, Enosawa S, Takeuchi T, Takezawa T.Cell Transplant. 2009;18(5):619-26. PMID: 19775524


51.

Reconstruction of three-dimensional human skin model composed of dendritic cells, keratinocytes and fibroblasts utilizing a handy scaffold of collagen vitrigel membrane.Uchino T, Takezawa T, Ikarashi Y.Toxicol In Vitro. 2009 Mar;23(2):333-7. PMID: 19121381


52.

Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2.Zhao J, Shinkai M, Takezawa T, Ohba S, Chung UI, Nagamune T. J BiosciBioeng. 2009 Mar;107(3):318-23. PMID: 19269600


53.

The osteogenic differentiation of adipose tissue-derived precursor cells in a 3D scaffold/matrix environment.Leong DT, Nah WK, Gupta A, Hutmacher DW, Woodruff MA.Curr Drug Discov Technol. 2008 Dec;5(4):319-27. PMID: 19075612


54.

Physical and biological properties of collagen-phospholipid polymer hybrid gels.Nam K, Kimura T, Kishida A.Biomaterials. 2007 Jul;28(20):3153-62. PMID: 17391753


55.

Preparation and characterization of cross-linked collagen-phospholipid polymer hybrid gels.Nam K, Kimura T, Kishida A.Biomaterials. 2007 Jan;28(1):1-8. PMID: 16959313


56.

Reconstruction of a hard connective tissue utilizing a pressed silk sheet and type-I collagen as the scaffold for fibroblasts.Takezawa T, Ozaki K, Takabayashi C.Tissue Eng. 2007 Jun;13(6):1357-66. PMID: 17518702


57.

Collagen vitrigel membrane useful for paracrine assays in vitro and drug delivery systems in vivo.Takezawa T, Takeuchi T, Nitani A, Takayama Y, Kino-Oka M, Taya M, Enosawa S.J Biotechnol. 2007 Aug 1;131(1):76-83. PMID: 17624459


58.

Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: influence of collagen type II extracellular matrix on MSC chondrogenesis.Bosnakovski D, Mizuno M, Kim G, Takagi S, Okumura M, Fujinaga T.BiotechnolBioeng. 2006 Apr 20;93(6):1152-63. PMID: 16470881


59.

Electrochemical properties of 316L stainless steel with culturing L929 fibroblasts.Hiromoto S, Hanawa T.J R Soc Interface. 2006 Aug 22;3(9):495-505. PMID: 16849246


60.

Fabrication of a new tubular fibrous PLCL scaffold for vascular tissue engineering.Kim SH, Kwon JH, Chung MS, Chung E, Jung Y, Kim SH, Kim YH.J Biomater Sci Polym Ed. 2006;17(12):1359-74. PMID: 17260508


61.

In vitro assays for adhesion and migration of osteoblastic cells (Saos-2) on titanium surfaces.Li CY, Gao SY, Terashita T, Shimokawa T, Kawahara H, Matsuda S, Kobayashi N.Cell Tissue Res. 2006 Jun;324(3):369-75. PMID: 16450122


62.

Novel tissue-engineered biodegradable material for reconstruction of vascular wall.Iwai S, Sawa Y, Taketani S, Torikai K, Hirakawa K, Matsuda H.Ann Thorac Surg. 2005 Nov;80(5):1821-7. PMID: 16242461


63.

Co-electrospun nanofiber fabrics of poly(L-lactide-co-epsilon-caprolactone) with type I collagen or heparin.Kwon IK, Matsuda T.Biomacromolecules. 2005 Jul-Aug;6(4):2096-105. PMID: 16004450


64.

In vitro and in vivo study of He+ ion irradiated collagen for development of small diameter stent graft material.Y. Suzuki, M. Iwaki, N. Takahashi, T. Yotoriyama, K. Kurotobi, H. Ujiie, T. Hori.Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Volume 232, Issues 1–4, May 2005, Pages 353-357.


65.

The changes of cell adhesion to collagen-coated Al2O3 by ion bombardment.Y. Yokoyama, T. Tsukamoto, T. Kobayashi, M. Iwaki.Surface and Coatings Technology, Volume 196, Issues 1–3, 22 June 2005, Pages 298-302.


66.

Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids.Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T. Cell Transplant. 2004;13(4):463-73. PMID: 15468688

I-AC凝胶上培养、其他

1.

Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline.Tomoko T. Asai, Kazunobu Yoshikawa, Kazuhiro Sawada, KazunaFukamizu, Yoh-ichi Koyama, Yasutaka Shigemura, Shiro Jimi, Kenji Sato.Journal of Functional Foods, Volume 66, 2020.


2.

Discovery of Ti-Binding Abilities of Phosphorylated-Chitin and -Collagen.Yoshinori Kuboki, Seiichi Tokura, KimitoshiYagami, ToshitakeFurusawa, Kouichi Morimoto, Qin Song, Souhei (Xiaobing) Iku, Masaaki Kurasaki.Journal of Hard Tissue Biology, 2020 29(1):45-48.


3.

Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide.Asai TT, Oikawa F, Yoshikawa K, Inoue N, Sato K.Int J Mol Sci. 2019 Dec 28;21(1). PMID: 31905705


4.

Development of a collagen-like peptide polymer via end-to-end disulfide cross-linking and its application as a biomaterial.Ichise SF, Takeuchi S, Aoki S, Kuroda KC, Nose H, Masuda R, Koide T.Acta Biomater. 2019 Aug;94:361-371. PMID: 31200119


5.

Analysis of Ultraviolet Radiation Wavelengths Causing Hardening and Reduced Elasticity of Collagen Gels In Vitro.Kazuhisa Maeda.Cosmetics 2018, 5(1), 14.


6.

Three-dimensional printed microfluidic modules for design changeable coaxial microfluidic devices.Yuya Morimoto, Mahiro Kiyosawa, Shoji Takeuchi.Sensors and Actuators B: Chemical, Volume 274, 2018, Pages 491-500.


7.

Amino Carbonylation of Epidermal Basement Membrane Inhibits Epidermal Cell Function and Is Suppressed by Methylparaben.HarukaMorimoto ,Lihao Gu , Haifeng Zeng and Kazuhisa Maeda.Cosmetics 2017, 4(4), 38.


8.

Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma.Villasante A, Sakaguchi K, Kim J, Cheung NK, Nakayama M, Parsa H, Okano T, Shimizu T, Vunjak-Novakovic G.Theranostics 2017; 7(17):4099-4117.


9.

Ultrastructural analysis of the decellularized cornea after interlamellar keratoplasty and microkeratome-assisted anterior lamellar keratoplasty in a rabbit model.Hashimoto Y, Hattori S, Sasaki S, Honda T, Kimura T, Funamoto S, Kobayashi H, Kishida A.Sci Rep. 2016 Jun 13;6:27734. PMID: 27291975


10.

Thermal denaturation behavior of collagen fibrils in wet and dry environment.Suwa Y, Nam K, Ozeki K, Kimura T, Kishida A, Masuzawa T.J Biomed Mater Res B Appl Biomater. 2016 Apr;104(3):538-45 PMID: 25952296


11.

Synergistic rate boosting of collagen fibrillogenesis in heterogeneous mixtures of crowding agents.Dewavrin JY, Abdurrahiem M, Blocki A, Musib M, Piazza F, Raghunath M.J Phys Chem B. 2015 Mar 26;119(12):4350-8. PMID: 25730613.


12.

Cellular characterization of thrombocytes in Xenopus laevis with specific monoclonal antibodies.Tanizaki Y, Ishida-Iwata T, Obuchi-Shimoji M, Kato T.Exp Hematol. 2015 Feb;43(2):125-36. PMID: 25448492


13.

Tuning the architecture of three-dimensional collagen hydrogels by physiological macromolecular crowding.Dewavrin JY, Hamzavi N, Shim VP, Raghunath M.Acta Biomater. 2014 Oct;10(10):4351-9. PMID: 24932771


14.

Migration of breast cancer cells into reconstituted type I collagen gels assessed via a combination of frozen sectioning and azan staining.Fukuda K, Kamoshida Y, Kurokawa T, Yoshida M, Fujita-Yamaguchi Y, Nakata M.Biosci Trends. 2014 Aug;8(4):212-6. PMID: 25224627


15.

Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvβ8 with type Ⅰ collagen.Hayashido Y, Kitano H, Sakaue T, Fujii T, Suematsu M, Sakurai S, Okamoto T.Int J Oncol. 2014 Nov;45(5):1875-82. PMID: 25190218


16.

Relationships between molecular mobility, fibrillogenesis of collagen molecules, and the inflammatory response: An experimental study in vitro and in vivo.Nam K, Seo JH, Kimura T, Yui N, Kishida A.J Colloid Interface Sci. 2014 Jul 1;433C:16-25. PMID: 25112908


17.

In vitro engineering of vascularized tissue surrogates.Sakaguchi K, Shimizu T, Horaguchi S, Sekine H, Yamato M, Umezu M, Okano T.Sci Rep. 2013 Feb 19;3:1316. PMID: 23419835


18.

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产品编号 产品名称 产品规格 产品等级
KOU-IPC-30 Atelocollagen, Bovine dermis, 3mg/mL 
去端肽胶原,牛皮来源,3 mg/mL
50ml/btl
KOU-IPC-50 Atelocollagen Bovine dermis 5mg/ml pH3.0 Steril 
去端肽胶原,牛皮来源,5 mg/mL
50ml/btl
KOU-IAC-30 Native collagen Bovine dermis 3mg/ml pH3.0 Steril 
天然胶原,牛皮来源,3 mg/mL
50ml/btl
KOU-IAC-50 Native collagen Bovine dermis 5mg/ml pH3.0 Steril 
天然胶原,牛皮来源,5 mg/mL
50ml/btl