Dkk-1 (rat), ELISA kit

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    • 货号：

      ADI-900-171

    • 保存条件：

      4°C

    • 供应商：

      上海金畔生物科技有限公司

    • 规格：

      96 孔

    灵敏度：26.1 pg/ml (range 39.1 – 1250 pg/ml)测定时间：3小时应用：大鼠细胞培养上清液、血浆和血清中Dkk-1含量的定量检测交叉反应：大鼠 Dkk-1 (100%) and <0.03%: 小鼠 Dkk-2, Dkk-4, Sgy-1 试剂盒包含：Microtiter plate, Conjugate, Antibody, Assay buffer 36, Wash buffer concentrate, Standard, TMB Substrate, Stop solution 2其它参数：Dkk-1 (Dickkopf-1) is a secreted inhibitor of the canonical Wnt signaling pathway, which mediates a variety of cellular processes including the growth and development of osteoblasts. Dkk-1 disrupts the canonical pathway by binding to the LRP5/6 co-receptors, preventing interaction with Wnt, and facilitating the degradation of beta-catenin. Dkk-1 is overexpressed in multiple myeloma, increasing bone resorption and the appearance of osteolytic lesions characteristic of multiple myeloma.

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