[pThr180/Tyr182]p38 ELISA kit

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  • 询价记录
  • 相关实验
    • 货号:

      ADI-900-101

    • 保存条件:

      4°C(仅标准品需‘-20℃)

    • 供应商:

      上海金畔生物科技有限公司

    • 规格:

      96 孔

    灵敏度:52.1 pg/ml (range 156 – 5,000 pg/ml)测定时间:3小时应用:用于人和小鼠细胞裂解液中[pThr180/Tyr182]p38的测定。交叉反应:Phospho p38 (100%) and <0.01%: non-phosphorylated p38, phospho Jnk, non-phosphorylated Jnk, AKT, non-phosphorylated Erk, phospho Erk试剂盒包含:Microtiter plate, Conjugate, Antibody, Assay buffer 4 concentrate, Wash buffer concentrate, Standard, TMB Substrate, RIPA Cell lysis buffer 2, Stop solution 2其它参数:Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38α (SAPK2, CSBP) and its splice variant Mxi; p38β and β2; p38γ (ERK6, SAPK3); and p38δ (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.

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