Selective and strong inhibitor of ROCK (Rho-associated coiled-coil forming kinase/Rho binding kinase). [ROCK: Serine/threonine kinase protein phosphoenzyme] Y-27632 inhibits contraction of the vascular smooth muscle, infiltration of cancer cells, and regulation of cell differentiation caused by a signal transduction system of ROCK. (Ki=140 nmol/L p160ROCK)Inactive gas (Ar gas) enclosed.

Highly potent, cell-permeable, selective ROCK inhibitor

Y-27632 is a highly potent, cell-permeable and selective inhibitor of Rho-associated coiled coil forming protein kinases (ROCK). As well as modulating smooth-muscle contraction by inhibiting Ca²⁺ sensitization, Rho/ROCK pathway may help to regulate integrin-mediated cell adhesion and motility, which could be critical in processes such as tumour-cell metastasisand immunoactivation. (Ki value of Y-27632 for p160^ROCK = 140 nmol/L ¹⁾

Solubility: H₂O (100 mg/mL) 
 

• Maintain ES & iPs cells in an undifferentiated state
• Improve reprogramming efficiency

Enhances survival rate after cryopreservation and cloning efficiency of human ES and iPS cells.

Reference:

1. Claassen, DA., et al.: Mol. Reprod. Dev., 76, 722 (2009)
2. Martin-lbanez, R., et al.: Hum. Reprod., 23, 2744 (2008)
3. Watanabe, K., et al.: Nature Biotechnol., 25, 681 (2007)
4. Sakamoto, K., et al.: J. Pharamacol. Sci., 92, 56 (2003)
5. Nishimaru, K., et al.: J. Pharamacol. Sci., 92, 424 (2003)
6. Uehata, M., et al.: Nature, 389, 990 (1997)

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253-00591 5mmol/l Y-27632 Solution  300μl
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